Results 351 to 360 of about 2,078,021 (401)

Protein kinase inhibitors and antibiotic resistance

Pharmacology & Therapeutics, 2002
While antibiotics revolutionized the treatment of infectious disease in the 20th century, bacterial resistance now threatens to render many of them ineffective. Aminoglycosides are a class of clinically important antibiotics used in the treatment of infections caused by Gram-positive and -negative organisms.
Albert M. Berghuis, David L. Burk
openaire   +3 more sources

The Protein Kinase C Inhibitor: Ruboxistaurin

2015
The isozyme protein kinase C (PKC) β is involved in several processes that are deregulated in different retinal cell types by hyperglycemia. This family of serine/threonine-specific protein kinases comprises several different members, which differ in their structure, cofactor requirement and substrate specificity.
Gabriele E. Lang, Heidrun L. Deissler
openaire   +2 more sources

Inhibitors of Protein KinasesCGP 41251, a Protein Kinase Inhibitor with Potential as an Anticancer Agent

Pharmacology & Therapeutics, 1999
CGP 41251 was originally identified as an inhibitor of protein kinase C (PKC), inhibiting mainly the conventional PKC subtypes, and subsequently shown to inhibit the vascular endothelial growth factor (VEGF) receptor kinase insert domain-containing receptor, which is involved in angiogenesis.
Thomas Meyer, Doriano Fabbro, Francesco Hofmann, Jürgen Mestan, Helmut Mett, Stefano Ferrari, Jeannette Wood, Elisabeth Buchdunger, Terence O'reilly   +8 more
openaire   +3 more sources

ChemInform Abstract: Metal Complexes as Protein Kinase Inhibitors

ChemInform, 2010
AbstractReview: iridium complexes; 13 refs.
Conrad Kunick, Ingo Ott
openaire   +4 more sources

Novel mitogen-activated protein kinase kinase inhibitors

Expert Opinion on Investigational Drugs, 2011
the development of new drugs over the last few decades has targeted specific proteins thought to be a key to the disease state. MAPK kinases 1 and 2 (commonly known as MEK1-2) represent such proteins as they lie downstream of important drug targets for oncology, such as EGFR, RAS and RAF.
Jeffrey N. Miner, Mark S. Chapman
openaire   +3 more sources

Physiological inhibitors of protein kinase C

Biochemical Pharmacology, 1996
Increasing numbers of proteins that have the capacity of interacting with protein kinase C isozymes in vitro and inhibiting their enzymatic activity in a noncompetitive manner have been purified. While these proteins can be hypothesized to be part of a tight regulatory system for protein kinase C enzymatic activity, critical examinations of the roles ...
openaire   +3 more sources

Discovery of Protein Kinase Phosphatase Inhibitors

2006
Dynamic protein phosphorylation, a major cellular regulatory system, is tightly controlled by coordinating the reversible action of protein kinases and phosphatases. Recent evidence is consistent with sophisticated mechanisms that regulate both kinases and phosphatases in the cell.
John S. Lazo, Andreas Vogt
openaire   +3 more sources

Physiological functions of protein kinase inhibitors

2000
Protein kinases are key regulatory enzymes involved in a multitude of biochemical pathways. This chapter will describe the current research on targeting specific protein kinases with inhibitors in attempts to disrupt flux through specific pathways.
M. Ho, John J. Turchi
openaire   +3 more sources

Inhibitors of protein kinases

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
Doriano Fabbro, David Shugar
openaire   +2 more sources

Properties of FDA-approved small molecule protein kinase inhibitors.

Pharmacological Research, 2019
R. Roskoski
semanticscholar   +1 more source