Results 141 to 150 of about 1,314,106 (300)

HUBUNGAN HIPERGLIKEMIA DENGAN AKTIVITAS PROTEIN KINASE C (PKC) PADA PENDERITA DIABETES MELITUS TIPE 2 [PDF]

, 2014
HUBUNGAN HIPERGLIKEMIA DENGAN AKTIVITAS PROTEIN KINASE C (PKC) PADA PENDERITA DIABETES MELITUS TIPE 2 CICA MARIA Latar Belakang: Diabetes Melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena ...
MARIA, CICA
core  

Fingolimod mitigates memory loss in a mouse model of Gulf War Illness amid decreasing the activation of microglia, protein kinase R, and NFκB. [PDF]

Neurotoxicology, 2023
Carreras I, Jung Y, Lopez-Benitez J, Tognoni CM, Dedeoglu A.   +4 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Protein Kinase R (PKR) Interacts with and Activates Mitogen-activated Protein Kinase Kinase 6 (MKK6) in Response to Double-stranded RNA Stimulation [PDF]

, 2004
Aristóbolo M. Silva, Mark Whitmore, Zan Xu, Zhengfan Jiang, Xiaoxia Li, Bryan Williams   +5 more
openalex   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Nek6 regulates autophagy through the mTOR signaling pathway to alleviate cerebral ischemia–reperfusion injury

Molecular Brain
Objective Cerebral ischemia–reperfusion injury (CIRI) is a major obstacle to neurological recovery after clinical treatment of ischemic stroke. The aim of this study was to investigate the molecular mechanism of Nek6 alleviating CIRI through autophagy ...
Qingzhi Wang, Xinjing Liu, Jing Yuan, Ting Yang, Lan Ding, Bo Song, Yuming Xu   +6 more
doaj   +1 more source

Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor‐2α in the central nervous system of SJL mice with experimental allergic encephalomyelitis [PDF]

, 2004
Anuradha Chakrabarty, Marsha Danley, Steven M. LeVine   +2 more
openalex   +1 more source

Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models. [PDF]

Sci Rep, 2022
Brombin C, Bagaglio S, Cugnata F, Castagna A, Uberti-Foppa C, Salpietro S, Di Serio C, Morsica G.   +7 more
europepmc   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source