Results 321 to 330 of about 2,497,817 (373)

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Protein Kinase R and the Inflammasome

Journal of Interferon & Cytokine Research, 2014
Protein kinase R (PKR) was first identified as a mediator of the double-stranded RNA (dsRNA)-mediated inhibition of protein synthesis in extracts from interferon-treated cells. In a physiological context, viral replication results in production of dsRNA, activation of PKR by autophosphorylation, and phosphorylation of the protein synthesis initiation ...
Howard C H, Yim, Bryan R G, Williams
openaire   +2 more sources

Protein kinase R and the metabolic syndrome

Journal of Cellular Biotechnology, 2015
Abstract Metabolic syndrome greatly increases the risk for developing metabolic and cardiovascular disorders and has reached epidemic proportions globally. Despite recent advances in medical science, scientific understandings on the root mechanisms of metabolic syndrome are still not fully understood, and such insufficient knowledge contributes to the ...
Bahal, Rishabh, Lakhani, Prit, Bhat, Audesh, Kondiparthi, Lavanya, Dhar, Indu, Desai, Kaushik, Dhar, Arti   +6 more
openaire   +1 more source

The Role of Protein Kinase R in the Interferon Response

Journal of Interferon & Cytokine Research, 2011
The effects of interferons (IFNs) are mediated through the induction of around 2,000 IFN-stimulated gene (ISG) products. However, the majority of these ISGs do not directly instigate IFN-mediated states, such as the defining resistance to viral infection.
Agnieszka, Pindel, Anthony, Sadler
openaire   +2 more sources

Structure and Function of the Protein Kinase R

2007
The protein kinase R (PKR) is an intracellular sensor of stress, exemplified by viral infection. Double-stranded (ds) RNA produced during viral replication activates PKR, which in turn arrests protein synthesis by phosphorylating the alpha subunit of the translation initiation factor eIF2.
A J, Sadler, B R G, Williams
openaire   +2 more sources

Design and synthesis of novel protein kinase R (PKR) inhibitors

Molecular Diversity, 2016
Protein kinase RNA-activated (PKR) plays an important role in a broad range of intracellular regulatory mechanisms and in the pathophysiology of many human diseases, including microbial and viral infections, cancer, diabetes and neurodegenerative disorders. Recently, several potent PKR inhibitors have been synthesized.
Sagiv, Weintraub, Tali, Yarnitzky, Shirin, Kahremany, Iliana, Barrera, Olga, Viskind, Kobi, Rosenblum, Masha Y, Niv, Arie, Gruzman   +7 more
openaire   +2 more sources

Kinase fusion proteins: intracellular R-proteins in plant immunity

Trends in Plant Science
Resistance (R) genes in the Triticeae tribe include not only genes encoding the canonical intracellular nucleotide-binding leucine-rich-repeat proteins (NLRs) but also genes encoding kinase fusion proteins (KFPs). Exploring these unconventional KFPs may expand the scope of effector-triggered immunity (ETI) and will have significant implications for ...
Yukun Liu, Shuguo Hou, Shisheng Chen
openaire   +2 more sources

Regulation of Protein Kinase R by Epstein-Barr Virus EBER1 RNA

Biochemistry, 2020
Protein kinase R (PKR) is a key antiviral component of the innate immune pathway and is activated by viral double-stranded RNAs (dsRNAs). Adenovirus-associated RNA 1 (VAI) is an abundant, noncoding viral RNA that functions as a decoy by binding PKR but not inducing activation, thereby inhibiting the antiviral response. In VAI, coaxial stacking produces
Cassie M. Zerbe, James L. Cole
openaire   +2 more sources

The role of protein kinase R in placental inflammation, mtUPR and apoptosis

Placenta, 2023
Placental inflammation is implicated in the pathophysiology of many pregnancy complications, including fetal growth restriction, preeclampsia, gestational diabetes, and choriocarcinoma. Mitochondrial dysfunction, one of the outcomes of placental inflammation, is characterized by loss of membrane potential, accumulation of oxygen radicals, mitochondrial
Umut Kerem, Kolac, Gizem, Donmez Yalcin, Ramazan, Karayel, Abdullah, Yalcin   +3 more
openaire   +2 more sources

1 REGULATION OF LKB1-DEPENDENT ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE BY PROTEIN KINASE C-z R.

Journal of Investigative Medicine, 2006
We previously reported the PI-3 kinase-dependent activation of the 59-AMP-activated kinase (AMPK) by peroxynitrite (ONOO2) and hypoxia-reoxygenation (H/R) in cultured endothelial cells. Here we show the molecular mechanism of activation of this pathway involves atypical protein kinase C (PKC)-z, a known downstream enzyme of PI-3 kinase, which leads to ...
Z. Xie, B. Davis, M. Zhang, M-H Zou
openaire   +1 more source