Results 331 to 340 of about 2,497,817 (373)

Protein kinase R(PKR)–like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015)

Expert Opinion on Therapeutic Patents, 2016
PKR-like endoplasmic reticulum kinase (PERK) is an essential component of the unfolded protein response (UPR) and a critical regulator of protein synthesis during endoplasmic reticulum (ER) stress. Transient PERK activation is protective; however, chronic ER stress and sustained PERK activation can be detrimental to cell health.
openaire   +2 more sources

Identification of new inhibitors of protein kinase R guided by statistical modeling

Bioorganic & Medicinal Chemistry Letters, 2011
We report the identification of new, structurally diverse inhibitors of interferon-induced, double-stranded RNA-activated protein kinase (PKR) using a combined experimental and computational approach. A training set with which to build a predictive statistical model was generated by screening a set of 80 known Ser/Thr kinase inhibitors against ...
Ruslana, Bryk, Kangyun, Wu, Brian C, Raimundo, Paul E, Boardman, Ping, Chao, Graeme L, Conn, Eric, Anderson, James L, Cole, Nigel P, Duffy, Carl, Nathan, John H, Griffin   +10 more
openaire   +2 more sources

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Nature, 1995
D. Cross, D. Alessi, P. Cohen, Mirjana Andjelkovich, B. Hemmings   +4 more
semanticscholar   +1 more source

dlg–R proteins: modified guanylate kinases

Nature Genetics, 1992
E V, Koonin, D F, Woods, P J, Bryant
openaire   +2 more sources

Mechanism of activation of protein kinase B by insulin and IGF‐1.

EMBO Journal, 1996
D. Alessi, M. Andjelkovic, Barry Caudwell, P. Cron, N. Morrice, P. Cohen, B. Hemmings   +6 more
semanticscholar   +1 more source

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Nature, 1994
John C. Lee, J. Laydon, P. Mcdonnell, T. Gallagher, Sanjay Kumar, D. Green, D. Mcnulty, Mary Jane Blumenthal, J. Keys, Scott W. Land vatter, J. Strickler, M. McLaughlin, I. R. Siemens, S. Fisher, G. P. Livi, J. White, J. Adams, P. Young   +17 more
semanticscholar   +1 more source

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

Science, 1998
J. Good, W. Ziegler, D. Parekh, D. Alessi, Philip R. Cohen, P. Parker   +5 more
semanticscholar   +1 more source

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

Science, 1997
H. Dudek, S. R. Datta, T. Franke, M. Birnbaum, R. Yao, G. Cooper, R. Segal, D. Kaplan, M. Greenberg   +8 more
semanticscholar   +1 more source

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly  

Highly accurate protein structure prediction with AlphaFold

Nature, 2021
John M Jumper, Richard Evans, Alexander Pritzel   +2 more
exaly