Results 291 to 300 of about 564,359 (343)
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A-kinase anchoring proteins: protein kinase A and beyond
Current Opinion in Cell Biology, 2000Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs).
Amelia S. Edwards, John D. Scott
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Current Opinion in Structural Biology, 1994
The structures of four serine/threonine protein kinases have been determined recently. By comparing these structures with that of the cAMP-dependent protein kinase (cAPK), it is now possible to see how the activity of these regulatory enzymes is controlled. Low activity is maintained through the conformation of the phosphorylation lip, domain rotations,
E J, Goldsmith, M H, Cobb
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The structures of four serine/threonine protein kinases have been determined recently. By comparing these structures with that of the cAMP-dependent protein kinase (cAPK), it is now possible to see how the activity of these regulatory enzymes is controlled. Low activity is maintained through the conformation of the phosphorylation lip, domain rotations,
E J, Goldsmith, M H, Cobb
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AGC protein kinase phosphorylation and protein kinase C
Biochemical Society Transactions, 2001Protein kinase cascades feature in many signal transduction pathways. For those discussed here, a single upstream protein kinase appears to be responsible for the control of multiple downstream targets. So how is specificity introduced into these events?
Parker, P J, Parkinson, S J
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2021
Recently, aging has been tried to be explained with large numbers of theories, but none of them can elucidate the changes occurring in the aging process alone. A unified theory encompassing the mechanisms of genetic factors and repair systems in aging is becoming increasingly required.
ENGİN, ATİLLA, ENGİN, AYŞE BAŞAK
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Recently, aging has been tried to be explained with large numbers of theories, but none of them can elucidate the changes occurring in the aging process alone. A unified theory encompassing the mechanisms of genetic factors and repair systems in aging is becoming increasingly required.
ENGİN, ATİLLA, ENGİN, AYŞE BAŞAK
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Journal of Cellular Physiology, 1986
The combined application of protein structural techniques, immunochemistry, and molecular biology has permitted an analysis of the differential expression of the genes for the three related protein kinases, C-alpha, -beta, and gamma. The evidence now suggests that the type of protein kinase C in a cell may govern the nature and mechanisms of functional
Axel Ullrich, Peter J. Parker
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The combined application of protein structural techniques, immunochemistry, and molecular biology has permitted an analysis of the differential expression of the genes for the three related protein kinases, C-alpha, -beta, and gamma. The evidence now suggests that the type of protein kinase C in a cell may govern the nature and mechanisms of functional
Axel Ullrich, Peter J. Parker
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A new family of protein kinases— The mitochondrial protein kinases
Advances in Enzyme Regulation, 1995Molecular cloning has provided evidence for a new family of protein kinases in eukaryotic cells. These kinases show no sequence similarity with other eukaryotic protein kinases, but are related by sequence to the histidine protein kinases found in prokaryotes. These protein kinases, responsible for phosphorylation and inactivation of the branched-chain
Yu Zhao +5 more
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Protein kinase ofAcetabularia [PDF]
Protoplasma, 1975 Acetabularia cells contain a protein kinase activity which transfers phosphate from ATP to serine or threonine residues of proteins. The enzyme does not respond to cAMP or cGMP. The specific activity increased during development and reached a maximum just before beginning of cap formation. The kinase appears to be a chloroplast associated enzyme.
Manfred Schweiger +6 more
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cAMP-dependent protein kinase and the protein kinase family
Faraday Discussions, 1992The structure of the catalytic subunit of cAMP-dependent protein kinase, the first protein kinase structure to be solved, is reviewed. The general architecture of the enzyme is described as well as the active site regions associated with substrate binding and catalysis.
Jianhua Zheng +4 more
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A-kinase anchoring protein targeting of protein kinase A in the heart
Journal of Molecular and Cellular Cardiology, 2004There is increasing evidence that subcellular targeting of signaling molecules is an important means of regulating the protein kinase A (PKA) pathway. Subcellular organization of the signaling molecules in the PKA pathway insures that a signal initiated at the receptor level is transferred efficiently to a PKA substrate eliciting some cellular response.
Meredith Bond +2 more
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