Results 81 to 90 of about 6,704,702 (410)

Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases

Pharmaceuticals, 2023
Cyclin-dependent kinases (CDKs) play diverse and critical roles in normal cells and may be exploited as targets in cancer therapeutic strategies. CDK4 inhibitors are currently approved for treatment in advanced breast cancer.
Mark Klein
doaj   +1 more source

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Journal of signal transduction, 2011
Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases that play the major role in signal transduction from the cell surface to the nucleus.
Yong Son, Y. Cheong, Nam‐Ho Kim, Hun-taeg Chung, D. Kang, H. Pae   +5 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis. [PDF]

, 2020
Kinases are involved in numerous critical cell signaling processes, and dysregulation in kinase signaling is implicated in many types of human cancers.
Guo, Lei, Huang, Ming, Li, Lin, Liu, Xiaochuan, Miao, Weili, Qi, Tianyu F, Wang, Yinsheng   +6 more
core   +1 more source

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]

, 2012
A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L., Eales, Katherine L.   +1 more
core   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations

BMC Genomics, 2008
Background Phosphorylation by protein kinases is a common event in many cellular processes. Further, many kinases perform specialized roles and are regulated by non-kinase domains tethered to kinase domain. Perturbation in the regulation of kinases leads
Martin Juliette, Anamika Krishanpal, Srinivasan Narayanaswamy   +2 more
doaj   +1 more source

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. [PDF]

, 2016
Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common features of most cancer types. CDKs have been shown to play important roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA ...
Duan, Zhenfeng, Hornicek, Francis J, Kan, Quancheng, Shen, Jacson K, Zhou, Yubing   +4 more
core   +1 more source

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Journal of Biology, 2003
Background The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by
S. Hawley, J. Boudeau, J. L. Reid, K. J. Mustard, Lina Udd, T. Mäkelä, D. Alessi, G. Hardie   +7 more
semanticscholar   +1 more source

Protein Kinase A Anchoring [PDF]

Journal of Biological Chemistry, 1997
Specificity is perhaps the most enigmatic property of hormonemediated signaling pathways, especially when one considers that more than 30 hormones employ the ubiquitous second messengers, Ca, phospholipid, or cAMP, to relay messages from the cell membrane to intracellular effectors.
Mark L. Dell'Acqua, John D. Scott
openaire   +3 more sources