Results 1 to 10 of about 914,048 (349)

Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

Antibodies, 2021
Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable.
Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland, Laurence Fayadat-Dilman   +8 more
doaj   +1 more source

Polymorphic amyloid nanostructures of hormone peptides involved in glucose homeostasis display reversible amyloid formation

Nature Communications, 2023
A large group of hormones are stored as amyloid fibrils in acidic secretion vesicles before they are released into the bloodstream and readopt their functional state.
Dániel Horváth, Zsolt Dürvanger, Dóra K. Menyhárd, Máté Sulyok-Eiler, Fruzsina Bencs, Gergő Gyulai, Péter Horváth, Nóra Taricska, András Perczel   +8 more
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The Budapest Amyloid Predictor and Its Applications

Biomolecules, 2021
The amyloid state of proteins is widely studied with relevance to neurology, biochemistry, and biotechnology. In contrast with nearly amorphous aggregation, the amyloid state has a well-defined structure, consisting of parallel and antiparallel β-sheets ...
László Keresztes, Evelin Szögi, Bálint Varga, Viktor Farkas, András Perczel, Vince Grolmusz   +5 more
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Single-chain dimers from de novo immunoglobulins as robust scaffolds for multiple binding loops

Nature Communications, 2023
Antibody derivatives have sought to recapitulate the antigen binding properties of antibodies, but with improved biophysical attributes convenient for therapeutic, diagnostic and research applications.
Jorge Roel-Touris, Marta Nadal, Enrique Marcos   +2 more
doaj   +1 more source

Selenate and selenite transporters in proso millet: Genome extensive detection and expression studies under salt stress and selenium

Frontiers in Plant Science, 2022
Crops are susceptible to a variety of stresses and amongst them salinity of soil is a global agronomic challenge that has a detrimental influence on crop yields, thus posing a severe danger to our food security.
Naveed Ul Mushtaq, Khalid M. Alghamdi, Seerat Saleem, Faamiya Shajar, Inayatullah Tahir, Ahmad Bahieldin, Reiaz Ul Rehman, Khalid Rehman Hakeem, Khalid Rehman Hakeem, Khalid Rehman Hakeem   +9 more
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The soybean (Glycine max L.) cytokinin oxidase/dehydrogenase multigene family; Identification of natural variations for altered cytokinin content and seed yield

Plant Direct, 2021
Cytokinins (CKs) play a fundamental role in regulating dynamics of organ source/sink relationships during plant development, including flowering and seed formation stages. As a result, CKs are key drivers of seed yield.
Hai Ngoc Nguyen, Shrikaar Kambhampati, Anna Kisiala, Mark Seegobin, Robert Joseph Neil Emery   +4 more
doaj   +1 more source

Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies

Antibodies, 2020
We report the novel crystal structure and characterization of symmetrical, homodimeric humanized heavy-chain-only antibodies or dimers (HC2s). HC2s were found to be significantly coexpressed and secreted along with mAbs from transient CHO HC/LC ...
Carl Mieczkowski, Soheila Bahmanjah, Yao Yu, Jeanne Baker, Gopalan Raghunathan, Daniela Tomazela, Mark Hsieh, Mark McCoy, Corey Strickland, Laurence Fayadat-Dilman   +9 more
doaj   +1 more source

Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells results in
Ute F. Röhrig, Somi Reddy Majjigapu, Pierre Vogel, Aline Reynaud, Florence Pojer, Nahzli Dilek, Patrick Reichenbach, Kelly Ascenção, Melita Irving, George Coukos, Olivier Michielin, Vincent Zoete   +11 more
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Protein Phosphatases Type 2C Group A Interact with and Regulate the Stability of ACC Synthase 7 in Arabidopsis

Cells, 2020
Ethylene is an important plant hormone that controls growth, development, aging and stress responses. The rate-limiting enzymes in ethylene biosynthesis, the 1-aminocyclopropane-1-carboxylate synthases (ACSs), are strictly regulated at many levels ...
Małgorzata Marczak, Agata Cieśla, Maciej Janicki, Anna Kasprowicz-Maluśki, Piotr Kubiak, Agnieszka Ludwików   +5 more
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MarkovFit: Structure Fitting for Protein Complexes in Electron Microscopy Maps Using Markov Random Field

Frontiers in Molecular Biosciences, 2022
An increasing number of protein complex structures are determined by cryo-electron microscopy (cryo-EM). When individual protein structures have been determined and are available, an important task in structure modeling is to fit the individual ...
Eman Alnabati, Juan Esquivel-Rodriguez, Genki Terashi, Daisuke Kihara, Daisuke Kihara   +4 more
doaj   +1 more source