Results 111 to 120 of about 914,048 (349)
Markov modeling of peptide folding in the presence of protein crowders
, 2018 We use Markov state models (MSMs) to analyze the dynamics of a $\beta$-hairpin-forming peptide in Monte Carlo (MC) simulations with interacting protein crowders, for two different types of crowder proteins [bovine pancreatic trypsin inhibitor (BPTI) and ...
Irbäck, Anders +2 more
core +1 more source
A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria [PDF]
, 2011 Fabien Llambi +7 more
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
SBILib: a handle for protein modeling and engineering. [PDF]
Bioinformatics, 2023 Gohl P +5 more
europepmc +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Protein folding, protein structure and the origin of life: Theoretical methods and solutions of dynamical problems [PDF]
Theoretical methods and solutions of the dynamics of protein folding, protein aggregation, protein structure, and the origin of life are discussed. The elements of a dynamic model representing the initial stages of protein folding are presented.
Weaver, D. L.
core +1 more source
Coarse-grain modelling of protein–protein interactions
Current Opinion in Structural Biology, 2013 Here, we review recent advances towards the modelling of protein-protein interactions (PPI) at the coarse-grained (CG) level, a technique that is now widely used to understand protein affinity, aggregation and self-assembly behaviour. PPI models of soluble proteins and membrane proteins are separately described, but we note the parallel development ...
Baaden, Marc, Marrink, Siewert J
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Journal of Pure and Applied MicrobiologyThe profound impacts of global changes on biodiversity necessitate a more comprehensive documentation, particularly at the microscale level. To achieve precise and rapid insights into this unique diversity, the choice of an ideal species candidate is ...
Supajit Sraphet +4 more
doaj +1 more source
Prediction of CD44 Structure by Deep Learning-Based Protein Modeling. [PDF]
Biomolecules, 2023 Camponeschi C +5 more
europepmc +1 more source