Results 201 to 210 of about 914,048 (349)

Results of the Protein Engineering Tournament: An Open Science Benchmark for Protein Modeling and Design. [PDF]

Proteins
Armer C, Kane H, Cortade DL, Redestig H, Estell DA, Yusuf A, Rollins N, Spinner A, Marks D, Brunette TJ, Kelly PJ, DeBenedictis E.   +11 more
europepmc   +1 more source

Additional file 4 of Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

, 2020
Liang‐Chin Huang, Wayland Yeung, Ye Wang, Huimin Cheng, Aarya Venkat, Sheng Li, Ping Ma, Khaled Rasheed, Natarajan Kannan   +8 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A Visual Environment for Data Driven Protein Modeling and Validation. [PDF]

IEEE Trans Vis Comput Graph
Falk M, Tobiasson V, Bock A, Hansen C, Ynnerman A.   +4 more
europepmc   +1 more source

Large-scale in vitro functional testing and novel variant scoring via protein modeling provide insights into alkaline phosphatase activity in hypophosphatasia. [PDF]

Hum Mutat, 2020
Del Angel G, Reynders J, Negron C, Steinbrecher T, Mornet E.   +4 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Numerical Evaluation of Protein Global Vibrations at Terahertz Frequencies by Means of Elastic Lattice Models [PDF]

, 2020
Domenico Scaramozzino, Giuseppe Lacidogna, Gianfranco Piana, Alberto Carpinteri   +3 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Deep Learning Enables Automatic Correction of Experimental HDX-MS Data with Applications in Protein Modeling. [PDF]

J Am Soc Mass Spectrom
Salmas RE, Borysik AJ.
europepmc   +1 more source

Comprehensive Antigen Screening Identifies Moraxella catarrhalis Proteins That Induce Protection in a Mouse Pulmonary Clearance Model

, 2013
Margarita Smidt, Patrick Bättig, Suzanne J. C. Verhaegh, Axel Niebisch, Markus Hanner, Sanja Selak, Wolfgang Schüler, Eva Morfeldt, Hellberg Christel, Eszter Nagy, Urban Lundberg, John P. Hays, Andreas Meinke, Birgitta Henriques‐Normark   +13 more
openalex   +2 more sources