Results 221 to 230 of about 914,048 (349)

Computational Modelling of Human Sarcomeric Telethonin Protein and Predicting the Functional effect of Missense Single Nucleotide Polymorphsim

, 2019
P. P. Anand
openalex   +1 more source

Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus [PDF]

, 2009
Di Wu, Tianlei Xu, Jing Sun, Jianxin Dai, Guohui Ding, Yungang He, Zhengfeng Zhou, Hui Xiong, Hui Dong, Weirong Jin, Chao Bian, Jin Li, Hongyan Wang, Xiaoning Wang, Zhong Yang, Zhong Yang, Hao Wang, Xiaoyan Che, Zhong Huang, Ke Lan, Bing Sun, Fan Wu, ZhenAn Yuan, Xi Zhang, Xiao‐Nong Zhou, Jiahai Zhou, Zhiyong Ma, Guangzhi Tong, Yajun Guo, Guoping Zhao, Yixue Li, Zhiwei Cao   +31 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Carbachol-induced contractile responses in rat colon are influenced by protein kinase C-inhibition in TNBS-induced colitis model

, 2018
Hiromi Nobe, Koji Nobe
openalex   +2 more sources

Effect of six-week high intensity interval training under simulated microgravity on tissue level of degenerated myelin basic protein (dgen-MBP) in a rat model

, 2021
Fateme Marali, Ali Kazemi, Farid Farhani
openalex   +1 more source

Protein Modelling [PDF]

, 2014
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Human tear fluid proteome dataset for usage as a spectral library and for protein modeling. [PDF]

Data Brief, 2019
Guntermann A, Steinbach S, Serschnitzki B, Grotegut P, Reinehr S, Joachim SC, Schargus M, Marcus K, May C.   +8 more
europepmc   +1 more source

Dapagliflozin Regulates Cardiac Metabolic Remodeling Partially via Uncoupling Protein 3 in a Nondiabetic Thoracic Aortic Constriction-Induced Mouse Model

, 2021
Liwen Bao, Rongchen Liu, Fangying Yan, Hui-Hua Fan, Guoqian Huang, Xiufang Gao, Kun Xie, Yong Li, Haiming Shi   +8 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source