Results 21 to 30 of about 914,048 (349)

Characterization of promoter elements of isoprene‐responsive genes and the ability of isoprene to bind START domain transcription factors

Plant Direct, 2023
Isoprene has recently been proposed to be a signaling molecule that can enhance tolerance of both biotic and abiotic stress. Not all plants make isoprene, but all plants tested to date respond to isoprene.
Sarathi M. Weraduwage, Abira Sahu, Martin Kulke, Josh V. Vermaas, Thomas D. Sharkey   +4 more
doaj   +1 more source

Four small puzzles that Rosetta doesn't solve [PDF]

, 2011
A complete macromolecule modeling package must be able to solve the simplest structure prediction problems. Despite recent successes in high resolution structure modeling and design, the Rosetta software suite fares poorly on deceptively small protein ...
A Leaver-Fay, A Onufriev, AG Cochran, Ashley M. Buckle, B Barua, B Kuhlman, B Qian, BM Olivera, C Simmerling, CA McPhalen, CA McPhalen, CA Rohl, CC Correll, CJ McKnight, CR Woese, D Chivian, D Rothlisberger, DJ Mandell, E Ennifar, F DiMaio, IK McDonald, JK Lassila, JM Blose, JW Neidigh, JW Pitera, KM Misura, KT Simons, KT Simons, L Jiang, LW Guddat, M Dauplais, O Schueler-Furman, P Bradley, P Brion, P Eastman, P Ren, R Bonneau, R Bonneau, R Das, R Das, R Das, R Das, R Das, R Das, R Kratzner, R Zhou, Rhiju Das, S Raman, S Raman, T Kortemme, XI Ambroggio, Y Shen   +51 more
core   +5 more sources

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology

Molecules, 2019
The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier, Michel Petitjean, Leslie Regad, Quentin Bayard, Manon Réau, Anne Badel, Anne-Claude Camproux   +6 more
doaj   +1 more source

In silico Characterization of Biofilm-Associated Protein (Bap) Identified in a Multi-drug Resistant Acinetobacter baumannii Clinical Isolate

Journal of Medical Microbiology and Infectious Diseases, 2021
Introduction: Acinetobacter baumannii (AB) is a Gram-negative bacteria associated with various hospital infections. The present study deals with in silico analysis of the biofilm-associated protein (Bap) in this pathogen.
Mohammad Reza Shakibaie1, 2
doaj   +1 more source

Critical assessment of methods of protein structure prediction: Progress and new directions in round XI [PDF]

, 2016
Modeling of protein structure from amino acid sequence now plays a major role in structural biology. Here we report new developments and progress from the CASP11 community experiment, assessing the state of the art in structure modeling. Notable points
Fidelis, Krzysztof, Kryshtafovych, Andriy, Moult, John, Schwede, Torsten, Tramontano, Anna   +4 more
core   +1 more source

Docking of protein models [PDF]

Protein Science, 2002
Abstract An adequate description of entire genomes has to include information on the three‐dimensional (3D) structure of proteins. Most of these protein structures will be determined by high‐throughput modeling procedures. Thus, a structure‐based analysis of the network of protein–protein interactions in genomes requires docking ...
Andrei, Tovchigrechko, Christopher A, Wells, Ilya A, Vakser   +2 more
openaire   +2 more sources

MODBASE, a database of annotated comparative protein structure models and associated resources. [PDF]

, 2008
MODBASE (http://salilab.org/modbase) is a database of annotated comparative protein structure models. The models are calculated by MODPIPE, an automated modeling pipeline that relies primarily on MODELLER for fold assignment, sequence-structure alignment,
Barkan, David T, Carter, Hannah, Davis, Fred P, Eramian, David, Eswar, Narayanan, Karchin, Rachel, Kelly, Libusha, Mankoo, Parminder, Marti-Renom, Marc A, Pieper, Ursula, Sali, Andrej, Webb, Ben M   +11 more
core   +2 more sources

The transmembrane supercomplex mediating the biogenesis of OMPs in Gram‐negative bacteria assumes a circular conformational change upon activation

FEBS Open Bio, 2020
The cell envelope of Gram‐negative bacteria is composed of the inner (plasma) and the outer membrane. In the outer membrane, the outer membrane β‐barrel proteins (OMPs) serve multiple functions.
Feng Jin
doaj   +1 more source

2D hybrid analysis: Approach for building three-dimensional atomic model by electron microscopy image matching

Scientific Reports, 2017
In this study, we develop an approach termed “2D hybrid analysis” for building atomic models by image matching from electron microscopy (EM) images of biological molecules.
Atsushi Matsumoto, Naoyuki Miyazaki, Junichi Takagi, Kenji Iwasaki   +3 more
doaj   +1 more source

Genetic evaluation of hyperphenylalaninemia patients with tetrahydrobiopterin deficiency in Iranian population: Identification of four novel disease‐causing variants

Molecular Genetics & Genomic Medicine, 2022
Background Hyperphenylalaninemia (HPA) is the most common inborn error of amino acid metabolism worldwide. At least 2% of HPA cases are caused by a deficiency in tetrahydrobiopterin (BH4) metabolism.
Seyedeh Helia Sadat Fatemi, Peyman Eshraghi, Mahmoud Ghanei, Tayebeh Hamzehloei   +3 more
doaj   +1 more source