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Modeling Peptide–Protein Interactions
2011Peptide-protein interactions are prevalent in the living cell and form a key component of the overall protein-protein interaction network. These interactions are drawing increasing interest due to their part in signaling and regulation, and are thus attractive targets for computational structural modeling.
Nir, London +2 more
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2016
Mercury (Hg) is a naturally occurring element that is released into the biosphere both by natural processes and anthropogenic activities. Although its reduced, elemental form Hg(0) is relatively nontoxic, other forms such as Hg(2+) and, in particular, its methylated form, methylmercury, are toxic, with deleterious effects on both ecosystems and humans.
J M, Parks, J C, Smith
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Mercury (Hg) is a naturally occurring element that is released into the biosphere both by natural processes and anthropogenic activities. Although its reduced, elemental form Hg(0) is relatively nontoxic, other forms such as Hg(2+) and, in particular, its methylated form, methylmercury, are toxic, with deleterious effects on both ecosystems and humans.
J M, Parks, J C, Smith
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Comparative Modeling of Proteins
2008Three-dimensional analysis of protein structures is proving to be one of the most fruitful modes of biological and medical discovery in the early 21st century, providing fundamental insight into many (perhaps most) biochemical functions of relevance to the cause and treatment of diseases. Fully realizing such insight, however, would require analysis of
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Accurate automatic protein models
Acta Crystallographica Section D Biological Crystallography, 2004A method for automatic building of protein structures has been developed. The method is based on the concept of flexible structure units. A structure unit is a fragment (group) of about ten atoms that is positioned in the electron density by a phased rotation and translation function.
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Probabilistic protein homology modeling
2014Searching sequence databases and building 3D models for proteins are important tasks for biologists. When the structure of a query protein is given, its function can be inferred. However, experimental methods for structure prediction are both expensive and time consuming.
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Multiscale Modeling of Proteins
Accounts of Chemical Research, 2009The activity within a living cell is based on a complex network of interactions among biomolecules, exchanging information and energy through biochemical processes. These events occur on different scales, from the nano- to the macroscale, spanning about 10 orders of magnitude in the space domain and 15 orders of magnitude in the time domain ...
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Homology Modeling of Protein Targets with MODELLER
2019Homology modeling is a computational approach to generate three-dimensional structures of protein targets when experimental data about similar proteins are available. Although experimental methods such as X-ray crystallography and nuclear magnetic resonance spectroscopy successfully solved the structures of nearly 150,000 macromolecules, there is still
Gabriela, Bitencourt-Ferreira +1 more
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2014
Protein-protein interactions lie at the heart of most cellular processes. Determining their high-resolution structures by experimental methods is a nontrivial task, which is why complementary computational approaches have been developed over the years.
van Zundert, Gydo C P +1 more
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Protein-protein interactions lie at the heart of most cellular processes. Determining their high-resolution structures by experimental methods is a nontrivial task, which is why complementary computational approaches have been developed over the years.
van Zundert, Gydo C P +1 more
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Protein structure homology modeling using SWISS-MODEL workspace
Nature Protocols, 2008Homology modeling aims to build three-dimensional protein structure models using experimentally determined structures of related family members as templates. SWISS-MODEL workspace is an integrated Web-based modeling expert system. For a given target protein, a library of experimental protein structures is searched to identify suitable templates. On the
Bordoli, L. +5 more
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Biochemistry and Cell Biology, 1995
Histidine-containing protein (HPr) is a central component of the bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS). This brief review covers recent structure–function studies on the active center of this protein: the role of the active center residues in phosphotransfer; the residues contributing to the phosphohydrolysis properties ...
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Histidine-containing protein (HPr) is a central component of the bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS). This brief review covers recent structure–function studies on the active center of this protein: the role of the active center residues in phosphotransfer; the residues contributing to the phosphohydrolysis properties ...
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