Results 31 to 40 of about 914,048 (349)
Biology, 2022 Yearly, 1,500,000 cases of leishmaniasis are diagnosed, causing thousands of deaths. To advance in its therapy, we present an interdisciplinary protocol that unifies ethnobotanical knowledge of natural compounds and the latest bioinformatics advances to ...
Adrián Vicente-Barrueco +3 more
doaj +1 more source
Protein Expression, Characterization and Activity Comparisons of Wild Type and Mutant DUSP5 Proteins [PDF]
, 2014 Background The mitogen-activated protein kinases (MAPKs) pathway is critical for cellular signaling, and proteins such as phosphatases that regulate this pathway are important for normal tissue development.
Gastonguay, Adam J. +11 more
core +2 more sources
Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect [PDF]
, 2013 Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently, they have been linked to aging of Escherichia coli (E. coli) where protein aggregates accumulate at the old pole region of the aging bacterium.
Berry, Hugues +8 more
core +12 more sources
LoopIng: A template-based tool for predicting the structure of protein loops [PDF]
, 2015 MOTIVATION: Predicting the structure of protein loops is very challenging, mainly because they are not necessarily subject to strong evolutionary pressure.
ABDEL MESSIH, MARIO ALFY FAHMY +2 more
core +1 more source
Modeling Zymogen Protein C [PDF]
Biophysical Journal, 2000 A solution structure for the complete zymogen form of human coagulation protein C is modeled. The initial core structure is based on the x-ray crystallographic structure of the gamma-carboxyglutamic acid (Gla)-domainless activated form. The Gla domain (residues 1-48) is modeled from the x-ray crystal coordinates of the factor VII(a)/tissue factor ...
Perera, Lalith +6 more
openaire +2 more sources
Frontiers in Genetics, 2022 Spinocerebellar ataxia (SCA) is a heterogeneous group of neurodegenerative disorders with autosomal dominant inheritance. Genetic testing for SCA leads to diagnosis, prognosis and risk assessment for patients and their family members.
Fatemeh Ghorbani +15 more
doaj +1 more source
Blind protein structure prediction using accelerated free-energy simulations. [PDF]
, 2016 We report a key proof of principle of a new acceleration method [Modeling Employing Limited Data (MELD)] for predicting protein structures by molecular dynamics simulation.
Brini, Emiliano +4 more
core +1 more source
Protein Structure Modeling with MODELLER
, 2014 Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized at atomic resolution using experimental structure determination methods.
Webb, Benjamin, Sali, Andrej
openaire +6 more sources
Biomedical and Biotechnology Research Journal, 2019 Objective: Rabies is a viral disease caused by the bite of an infected animal commonly a dog majorly affecting people in Africa and Asia and is extremely fatal if the infected person is not vaccinated.
Tehseen M Dhorajiwala +2 more
doaj +1 more source
Hybrid modeling, HMM/NN architectures, and protein applications [PDF]
, 1996 We describe a hybrid modeling approach where the parameters of a model are calculated and modulated by another model, typically a neural network (NN), to avoid both overfitting and underfitting.
Baldi, Pierre, Chauvin, Yves
core +1 more source