Results 41 to 50 of about 914,048 (349)

Genome-wide identification, comprehensive characterization of transcription factors, cis-regulatory elements, protein homology, and protein interaction network of DREB gene family in Solanum lycopersicum

open access: yesFrontiers in Plant Science, 2022
Tomato is a drought-sensitive crop which has high susceptibility to adverse climatic changes. Dehydration-responsive element-binding (DREB) are significant plant transcription factors that have a vital role in regulating plant abiotic stress tolerance by
Hajra Maqsood   +3 more
doaj   +1 more source

Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. [PDF]

open access: yes, 2016
This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function.
Chang, Chia-En A   +3 more
core   +2 more sources

A Conservative Replacement in the Transmembrane Domain of SARS-CoV-2 ORF7a as a Putative Risk Factor in COVID-19

open access: yesBiology, 2021
The ongoing COVID-19 pandemic follows an unpredictable evolution, driven by both host-related factors such as mobility, vaccination status, and comorbidities and by pathogen-related ones.
Andrei Lobiuc   +4 more
doaj   +1 more source

A Hierarchical Approach to Protein Molecular Evolution [PDF]

open access: yes, 1999
Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with Monte Carlo ...
Crameri   +30 more
core   +2 more sources

Fatgraph models of proteins [PDF]

open access: yesCommunications on Pure and Applied Mathematics, 2010
AbstractWe introduce a new model of proteins that extends and enhances the traditional graphical representation by associating a combinatorial object called a fatgraph to any protein based upon its intrinsic geometry. Fatgraphs can easily be stored and manipulated as triples of permutations, and these methods are therefore amenable to fast computer ...
Penner, Robert   +3 more
openaire   +3 more sources

Biological Machine Learning Combined with Campylobacter Population Genomics Reveals Virulence Gene Allelic Variants Cause Disease

open access: yesMicroorganisms, 2020
Highly dimensional data generated from bacterial whole-genome sequencing is providing an unprecedented scale of information that requires an appropriate statistical analysis framework to infer biological function from populations of genomes.
DJ Darwin R. Bandoy, Bart C. Weimer
doaj   +1 more source

The promises of large language models for protein design and modeling

open access: yesFrontiers in Bioinformatics, 2023
The recent breakthroughs of Large Language Models (LLMs) in the context of natural language processing have opened the way to significant advances in protein research. Indeed, the relationships between human natural language and the “language of proteins”
Giorgio Valentini   +12 more
doaj   +1 more source

Continuum Electromechanical Modeling of Protein-Membrane Interaction

open access: yes, 2010
A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system.
Alemayehu A. Gorfe   +4 more
core   +1 more source

Advances in protein tertiary structure prediction

open access: yesBiomedical and Biotechnology Research Journal, 2018
Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity.
Tayebeh Farhadi
doaj   +1 more source

Generative Adversarial Learning of Protein Tertiary Structures

open access: yesMolecules, 2021
Protein molecules are inherently dynamic and modulate their interactions with different molecular partners by accessing different tertiary structures under physiological conditions. Elucidating such structures remains challenging.
Taseef Rahman   +3 more
doaj   +1 more source

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