Results 61 to 70 of about 914,048 (349)

Giardia fatty acyl-CoA synthetases as potential drug targets

Frontiers in Microbiology, 2015
Giardiasis caused by Giardia intestinalis (syn. G. lamblia, G. duodenalis) is one of the leading causes of diarrheal parasitic diseases worldwide. Although limited drugs to treat giardiasis are available, there are concerns regarding toxicity in some ...
Fengguang eGuo, M. Guadalupe eOrtega-Pierres, Raúl eArgüello-García, Haili eZhang, Guan eZhu   +4 more
doaj   +1 more source

Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands [PDF]

, 2019
In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
Hagenow, Stefanie, Schaller, David, Stark, Holger, Wolber, Gerhard   +3 more
core   +2 more sources

SWISS-MODEL: an automated protein homology-modeling server [PDF]

Nucleic Acids Research, 2003
SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server computed 120 000 user requests for 3D protein models. SWISS-
Schwede, T., Kopp, J., Guex, N., Peitsch, M. C.   +3 more
openaire   +5 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Hot-spot analysis for drug discovery targeting protein-protein interactions [PDF]

, 2018
Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging.
Fernández-Recio, Juan, Rosell, Mireia
core   +2 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Computational Molecular Phenotypic Analysis of PTPN22 (W620R), IL6R (D358A), and TYK2 (P1104A) Gene Mutations of Rheumatoid Arthritis

Frontiers in Genetics, 2019
Rheumatoid arthritis (RA) is a chronic autoimmune disorder of bone joints caused by the complex interplay between several factors like body physiology, the environment with genetic background.
Noor Ahmad Shaik, Noor Ahmad Shaik, Babajan Banaganapalli, Babajan Banaganapalli   +3 more
doaj   +1 more source

Rare variant burden analysis from exomes of three consanguineous families reveals LILRB1 and PRSS3 as potential key proteins in inflammatory bowel disease pathogenesis

Frontiers in Medicine, 2023
BackgroundInflammatory bowel disease (IBD) is a chronic autoimmune disorder characterized by severe inflammation and mucosal destruction of the intestine.
Rana Mohammed Jan, Rana Mohammed Jan, Huda Husain Al-Numan, Huda Husain Al-Numan, Nada Hassan Al-Twaty, Nuha Alrayes, Nuha Alrayes, Hadeel A. Alsufyani, Meshari A. Alaifan, Bakr H. Alhussaini, Noor Ahmad Shaik, Noor Ahmad Shaik, Zuhier Awan, Yousef Qari, Omar I. Saadah, Omar I. Saadah, Babajan Banaganapalli, Babajan Banaganapalli, Mahmoud Hisham Mosli, Mahmoud Hisham Mosli, Ramu Elango, Ramu Elango   +21 more
doaj   +1 more source

NetSolP: predicting protein solubility in Escherichia coli using language models [PDF]

, 2021
Vineet Thumuluri, Hannah-Marie Martiny, José Juan Almagro Armenteros, Jesper Salomon, Henrik Nielsen, Alexander Rosenberg Johansen   +5 more
openalex   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source