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Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization
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The cysteine string protein multimeric complex
Biochemical and Biophysical Research Communications, 2006Cysteine string protein (CSPalpha) is a member of the cellular folding machinery that is located on regulated secretory vesicles. We have previously shown that CSPalpha in association with Hsc70 (70kDa heat shock cognate protein) and SGT (small glutamine-rich tetratricopeptide repeat domain protein) is a guanine nucleotide exchange factor (GEF) for G ...
Leigh Anne, Swayne +2 more
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On Monomeric and Multimeric Structures-Based Protein-Ligand Interactions
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2022Many ligands simultaneously interact with multiple protein chains in quaternary structure (QS). However, a significant number of previous studies on template-based modeling of protein-ligand interactions were based on monomeric structure (MS), which may suffer from incomplete binding information.
Yajun Dai +4 more
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Defining the Stability of Multimeric Proteins
2008The practical application of scanning calorimetry and spectroscopic methods to measure the stability of multimeric proteins is described. Oligomeric proteins are stabilized by both the intrinsic folding energy of the subunits as well as interactions between the subunits.
John W, Shriver, Stephen P, Edmondson
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Folding and association of oligomeric and multimeric proteins
2000Publisher Summary This chapter deals with the formation of the native tertiary and quaternary structure of proteins— that is, with the sequentially ordered folding/ association reaction. In discussing the mechanisms involved in both processes, available information originates exclusively from in vitro denaturation/ renaturation studies, suggesting ...
R, Jaenicke, H, Lilie
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Structures of Multimeric Proteins by NMR
1996Recent advances in NMR methodology, in particular the increase in resolution afforded by the advent of three- and four-dimensional NMR (see Clore & Gronenborn, 1991 for a review) have permitted the structures of proteins in the 15-25 kDa range to be solved in solution.
G. Marius Clore, Angela M. Gronenborn
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Functional genomic dissection of multimeric protein families in zebrafish
Developmental Dynamics, 2003AbstractThe study of multimeric protein function in the postgenomicera has become complicated by the discovery of multiple isoforms for each subunit of those proteins. A correspondingly large number of potential isoform combinations offer the multicellular organism a constellation of protein assemblies from which to generate a variety of functions ...
Keith C, Cheng +2 more
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Enhancing immunoassay detection of antigens with multimeric protein Gs
Biosensors and Bioelectronics, 2011This paper describes a method for the effective and self-oriented immobilization of antibodies on magnetic silica-nanoparticles using a multimeric protein G. Cysteine-tagged recombinant dimers and trimers of protein G were produced in Escherichia coli BL21 by repeated linking of protein G monomers with a flexible (GGGGS)(3) linker. Amino-functionalized
Jin Hyung, Lee +4 more
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