A novel proteomics workflow for simultaneous analysis of protein phosphorylation and <i>S</i>-nitrosylation. [PDF]
Zhang W +8 more
europepmc +1 more source
A Review of Machine Learning and Algorithmic Methods for Protein Phosphorylation Site Prediction. [PDF]
Esmaili F +4 more
europepmc +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
EPSD 2.0: An Updated Database of Protein Phosphorylation Sites Across Eukaryotic Species. [PDF]
Chen M +9 more
europepmc +1 more source
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
An atlas of protein phosphorylation dynamics during interferon signaling. [PDF]
Busnadiego I +5 more
europepmc +1 more source
Protein Kinase A-Mediated Inhibition of Gamma Interferon-Induced Tyrosine Phosphorylation of Janus Kinases and Latent Cytoplasmic Transcription Factors in Human Monocytes byEhrlichia chaffeensis [PDF]
Eunjoo H. Lee, Yasuko Rikihisa
openalex +1 more source
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin +6 more
wiley +1 more source
Differential responses to acute endurance exercise-induced signaling protein phosphorylation and abundance alterations in whole murine gastrocnemius muscle and isolated myofibers. [PDF]
Uemichi K +3 more
europepmc +1 more source

