Results 51 to 60 of about 7,148,227 (413)

Determination of VPS34/PIK3C3 Activity in vitro Utilising 32P-γATP

Bio-Protocol, 2016
VPS34 is the only class III phosphatidylinositol-3-kinase (PI3K) in mammalian cells and produces the vast majority of cellular phosphatidylinositol-3-phosphate [PI(3)P].
Michael Munson, Ian Ganley
doaj   +1 more source

OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program [PDF]

, 2019
A paradox is posed by metazoan gene-regulatory networks (GRNs) that are robust yet evolvable. Insight may be obtained through studies of bistable genetic circuits mediating developmental decisions. A model in organogenesis is provided by the sex-specific
Chen, Yen-Shan, Phillips, Nelson, Racca, Joseph, Weiss, Michael   +3 more
core   +1 more source

Protein phosphorylation in cyanobacteria [PDF]

Microbiology, 1994
The post-translational modification of proteins by phosphorylation may take a variety of forms, but in essence it is always a component of a process of adaptation that enables cells to sense and respond to changes in their external or internal environments.
openaire   +2 more sources

Protein phosphorylation and its role in archaeal signal transduction

FEMS Microbiology Reviews, 2016
Reversible protein phosphorylation is the main mechanism of signal transduction that enables cells to rapidly respond to environmental changes by controlling the functional properties of proteins in response to external stimuli.
D. Esser, L. Hoffmann, T. K. Pham, C. Bräsen, Wen Qiu, P. Wright, S. Albers, B. Siebers   +7 more
semanticscholar   +1 more source

Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria

Frontiers in Microbiology, 2016
In all living organisms, the phosphorylation of proteins modulates various aspects of their functionalities. In eukaryotes, protein phosphorylation plays a key role in cell signaling, gene expression, and differentiation.
Transito Garcia-Garcia, S. Poncet, A. Derouiche, Lei Shi, I. Mijakovic, M. Noirot-Gros   +5 more
semanticscholar   +1 more source

Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R [PDF]

, 2000
Background: Vaccinia virus gene B1R encodes a erine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection.
Beaud, G., Brown, N.G., Hardie, G., Leader, D.P., Morrice, D.N.   +4 more
core   +3 more sources

Corrigendum: Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation

Scientific Reports, 2016
Protein phosphorylation is an important post-translational modification of proteins. Postmortem tissues are widely being utilized in the biomedical studies, but the effects of postmortem on protein phosphorylation have not been received enough attention.
Yifan Wang, Yanchong Zhang, Wen Hu, Shutao Xie, C. Gong, K. Iqbal, Fei Liu   +6 more
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

eLife, 2017
Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain via ...
Atul Kumar, Jevgenia Tamjar, Andrew D Waddell, Helen I Woodroof, Olawale G Raimi, Andrew M Shaw, Mark Peggie, Miratul MK Muqit, Daan MF van Aalten   +8 more
doaj   +1 more source

Whole proteome copy number dataset in primary mouse cortical neurons

Data in Brief, 2023
The functional diversity of neurons is specified through their proteome resulting in elaborate and tightly regulated protein interaction networks and signalling that regulates neuronal processes.
Odetta Antico, Raja S. Nirujogi, Miratul M.K. Muqit   +2 more
doaj   +1 more source