Results 211 to 220 of about 356,376 (266)

Nucleation precursors in protein crystallization [PDF]

open access: yesActa Crystallographica Section F, Structural Biology Communications, 2014
Protein crystal nucleation is a central problem in biological crystallography and other areas of science, technology and medicine. Recent studies have demonstrated that protein crystal nuclei form within crucial precursors. Here, methods of detection and characterization of the precursors are reviewed: dynamic light scattering, atomic force microscopy ...
Peter G Vekilov
exaly   +3 more sources

Amyloid precursor protein and mitochondria

Current Opinion in Neurobiology, 2023
Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Taylor A. Strope, Heather M. Wilkins
openaire   +2 more sources

Sequence of an antifreeze protein precursor

European Journal of Biochemistry, 1984
The amino acid sequence of the precursor to the second-most-abundant serum antifreeze protein (B) in the winter flounder has been determined by a combination of protein and DNA sequencing. The precursor is an 82-residue preproprotein which differs in only three positions from the amino acid sequence of the precursor for the most-abundant serum ...
M, Pickett   +5 more
openaire   +2 more sources

Precursors of Embryonic Chick Proteins

Nature, 1956
WE wish to report some preliminary findings obtained in the course of a rather extensive investigation into the nature of precursors of embryonic chick proteins (for some recent reviews, see refs. 1 and 2). In these experiments, amino-acids, chicken serum globulin and ovalbumin, labelled in their sulphur amino-acids with sulphur-35, were prepared ...
A, BULBENKO, H R, MAHLER, H, WALTER
openaire   +2 more sources

The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins

Neurodegenerative Diseases, 2006
It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte, Anliker, Ulrike, Müller
openaire   +2 more sources

Early emergence of protein precursors

Advances in Space Research, 1986
For the emergence of protein precursors essential to primitive cells three prerequisites must have been fulfilled: selective aqueous polymerization of proteinaceous amino acids from a complex mixture of small organic compounds, selection of homochiral amino acid sequences and catalytic activity with respect, more precisely, to information transfer ...
openaire   +2 more sources

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