Results 221 to 230 of about 356,376 (266)

NUCLEIC ACID PRECURSORS AND PROTEIN SYNTHESIS [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1954
Arthur B Pardee, Pardee Arthur B
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Eukaryotic protein processing: endoproteolysis of precursor proteins

Current Opinion in Biotechnology, 1997
Limited endoproteolysis of biologically inactive polypeptide precursors is a general mechanism generating a diversity of biologically active peptides and proteins in all eukaryotic phyla. One of the major recognition motifs involves cleavage at either specific single or pairs of basic residues of the general formula (R/K) - Xn - (R/K) decreases, where ...
N G, Seidah, M, Chrétien
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Bioinformatic Analysis of Peptide Precursor Proteins

Annals of the New York Academy of Sciences, 2005
Abstract: Neuropeptides are among the most important signal molecules in animals. Traditional identification of peptide hormones through peptide purification is a tedious and time‐consuming process. With the advent of the genome sequencing projects, putative peptide precursor can be mined from the genome.
G, Baggerman, F, Liu, G, Wets, L, Schoofs   +3 more
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Function of amyloid and amyloid protein precursor

Clinical Neurology and Neurosurgery, 1992
A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
R A, Roos, J, Haan
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Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
D, Schubert, G, Cole, T, Saitoh, T, Oltersdorf   +3 more
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Amyloid Precursor Protein Is Found in Lysosomes

Gerontology, 2009
The major component of Alzheimer’s disease amyloid is a small polypeptide referred as the amyloid β protein, which is derived from a larger precursor, amyloid precursor protein (APP). Cell fractionation and immunological studies on the APP molecule indicate that APP is localized either in the neuron and astrocyte and that the molecule is recovered from
K, Tagawa, M, Yazaki, T, Kinouchi, K, Maruyama, H, Sorimachi, T, Tsuchiya, K, Suzuki, S, Ishiura   +7 more
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The pharmacology of amyloid precursor protein processing

Experimental Gerontology, 2003
The possibility to understand the causes and treat the symptoms of Alzheimer's disease patients is still a great challenge. The triggering events leading to the selective neurodegeneration observed in Alzheimer's brains are not completely understood.
RACCHI, MARCO, GOVONI, STEFANO
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Identification of microRNA Precursor-Associated Proteins

2018
MicroRNA (miRNA) biogenesis is regulated intricately at multiple levels. In addition to transcriptional control of pri-miRNA loci, sequence as well as structural features of the pri-miRNA-stem loop determine its processing efficiency by the endonucleases Drosha and Dicer.
Thomas, Treiber, Nora, Treiber, Gunter, Meister   +2 more
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Processing of precursor proteins by plant mitochondria

Archives of Biochemistry and Biophysics, 1990
Precursor proteins from Neurospora crassa were correctly processed by a matrix extract from Vicia faba and cauliflower mitochondria. Processing yielded mature protein of the same molecular mass as mature Neurospora protein. The processing activity has two components.
J, Whelan, P, O'Mahony, M A, Harmey
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The Mitochondrial Machinery for Import of Precursor Proteins

2007
Mitochondria contain a small genome that codes for approx 1% of the total number of proteins that reside in the mitochondria. Hence, most mitochondrial proteins are encoded for by the nuclear genome. After transcription in the nucleus these proteins are synthesized by cytosolic ribosomes.
Kipros, Gabriel, Nikolaus, Pfanner
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