Results 221 to 230 of about 19,078,260 (300)

Caspase-2 is a condensate-mediated deubiquitinase in protein quality control. [PDF]

Nat Cell Biol
Ge Y, Zhou L, Fu Y, He L, Chen Y, Li D, Xie Y, Yang J, Wu H, Dai H, Peng Z, Zhang Y, Yi S, Wu B, Zhang X, Zhang Y, Ying W, Cui CP, Liu CH, Zhang L.   +19 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Quality Management, Quality Assurance and Quality Control in Blood Establishments

Quality terms and the roots of the matter are analyzed according to European Committee’s recommendations. Essence of process and product quality control as well as essence of quality assurance is described. Quality system’s structure including quality
Bolbate, Natālija
core  

Augmented capacity to clear misfolded proteins: An intrinsic characteristic of tumor cells?

Molecular & Cellular Oncology, 2017
Liang Chen, Lili Guo, Xiaolu Yang
doaj   +1 more source

Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets. [PDF]

Cardiovasc Diabetol
Delalat S, Sultana I, Osman H, Sieme M, Zhazykbayeva S, Herwig M, Budde H, Kovács Á, Kaçmaz M, Göztepe E, Borgmann N, Shahriari G, Sasko B, Wintrich J, Haldenwang P, Schmidt WE, Fenske W, Khan M, Jaquet K, Mügge A, Máthé D, Tóth VE, Varga ZV, Ferdinandy P, El-Battrawy I, van Heerebeek L, Hamdani N.   +26 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

A drug candidate for a rare polyalanine disease targeting the protein quality control. [PDF]

Mol Ther Nucleic Acids
Pochtar S, Ashkenazi A.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Developing the protein quality control system in <i>Streptomyces</i> for selective translation of ultra-long full-length polyketide synthase mRNAs to enhance biosynthesis efficiency. [PDF]

Synth Syst Biotechnol
Jiang C, Hao K, Wang S, Guo R, Li X, Lv L, Luan J, Wang H.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source