Results 171 to 180 of about 24,775,971 (291)

Esophageal variceal bleeding: portal hypertension and portal vein thrombosis secondary to protein S deficiency - a case report. [PDF]

Ann Med Surg (Lond), 2023
Sapkota P, Mainali S, Khadayat P, K C N, Joshi A, Koirala P.   +5 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Internal thoracic artery aneurysm coincidental with protein S deficiency: a case report. [PDF]

Int J Emerg Med
Sano T, Maki Y, Sugiura H, Morishita E, Shinmoto H, Kawana A, Kimizuka Y.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Protein S Levels to Guide Exon-Level Copy Number Variant Analysis of <i>PROS1</i> for Confirming Hereditary Protein S Deficiency: A 10-Year Single-Center Experience. [PDF]

Ann Lab Med
Yu S, Park MS, Kim HY, Park TK, Chang SA, Kim DK, Kim HJ.   +6 more
europepmc   +1 more source

Protein S Deficiency and COVID-19: A Brutal Combination Leading to Acute Submassive Bilateral Pulmonary Embolism. [PDF]

Cureus, 2023
Chirumamilla Y, Almerstani Y, Marcus H, Bachuwa G.   +3 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Moyamoya Syndrome (MMS) in a Patient With Sickle Cell Disease (SCD) and Protein S Deficiency. [PDF]

Cureus, 2023
Saxena P, Alkaissi H, Chauhan R, Muthu J.   +3 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Multidisciplinary Treatment for Multiple Dural Arteriovenous Fistulas/Arteriovenous Malformation Associated with Congenital Protein S Deficiency: A Case Report and Literature Review. [PDF]

NMC Case Rep J
Ogawa S, Koizumi S, Hirata T, Umekawa M, Fujitani S, Shinya Y, Ono H, Miyawaki S, Nishikawa M, Kurokawa M, Saito N.   +10 more
europepmc   +1 more source