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Analytical Considerations for Free Protein S Assays in Protein S Deficiency

Thrombosis and Haemostasis, 2001
SummaryProtein S is an anticoagulant protein that circulates in plasma in complex with C4b-binding protein (C4BP) or in free form. Deficiency of protein S increases the risk of venous thrombosis. Measurement of free protein S, as compared to total levels, has been shown to be superior for prediction of protein S deficiency.
K E, Persson, A, Hillarp, B, Dahlbäck
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Protein S Deficiency

Thrombosis and Haemostasis, 1997
The protein C (PC) pathway, with its cofactor protein S (PS), is an important natural antithrombotic mechanism. Patients with phenotypic PS deficiency may develop recurrent thrombosis during adulthood, with a probability of remaining free of thrombosis of about 50% at age 45.
D, Borgel, S, Gandrille, M, Aiach
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Acquired protein S deficiency

The Clinical Investigator, 1992
Hereditary deficiencies of coagulation inhibitors like antithrombin III, protein C and protein S lead to an enhanced incidence of thromboembolic complications. Recently, acquired deficiencies of protein S were described in several disease states in which thromboembolic complications frequently occur. These acquired protein S deficiencies reach--in part-
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Hereditary Protein S Deficiency

Haemostasis, 2009
Protein S is a vitamin K-dependent plasma protein that serves as a cofactor of activated protein C (APC) in its inhibitory action on activated factor V and factor VIII and in its stimulation of fibrinolytic activity. In plasma, part of the protein S is complexed with the C4b-binding protein. Only the free protein S has APC cofactor activity.
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Moyamoya syndrome with protein S deficiency

European Journal of Paediatric Neurology, 2000
Moyamoya disease is a cerebrovascular disease with progressive occlusion of both internal carotid arteries and of their branches and formation of a new vascular network at the base of the brain. Because of the angiographic appearance, it is named as moyamoya.
D, Akgün, S, YiLmaz, N, Senbil, B, Aslan, Y Y, Gürer   +4 more
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Analysis of the Protein S Gene in Protein S Deficiency

2003
Protein S (PS) is a 71-kDa vitamin K-dependent glycoprotein first identified in human plasma by DiScipio and colleagues in 1977 (1), a year after the discovery of the anticoagulant protein C (PC) (2,3). A few years later, Walker demonstrated that PS acts as a cofactor for activated protein C (APC) in the proteolytic inactivation of the procoagulant ...
N, Sala, Y, Espinosa-Parrilla
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Arterial thrombosis and protein S deficiency

The Journal of Pediatrics, 1992
A previously healthy boy had progressive painful discoloration of the lower extremities and was treated with exchange transfusion and anticoagulation, which were unsuccessful in arresting pedal ischemia; amputation of all of the child's toes was required. Studies of the patient and his parents resulted in a diagnosis of inherited protein S deficiency.
I N, Horowitz, A G, Galvis, E D, Gomperts   +2 more
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Serendipitous Diagnosis of Protein S Deficiency

Journal of Periodontology, 2002
A 46‐year‐old male sought periodontal care for a swelling on his right mandibular gingiva. An excisional biopsy revealed a well‐differentiated squamous cell carcinoma. Surgical treatment consisted of a right segmental mandibulectomy with ipsilateral right neck dissection and fibular free flap reconstruction.
A, Aguirre, J L, Tapia, S, Ciancio, J, Coniglio   +3 more
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Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies

BJOG: An International Journal of Obstetrics & Gynaecology, 1997
Objective The aim of our study was to investigate whether women with placental abruption, intrauterine fetal death or small for gestational age infants have metabolic and/or haemostatic abnormalities which are known to be risk factors for intravascular thrombosis.Design For two years blood tests were performed at > 10 weeks after ...
de Vries, J.I.P., Dekker, G.A., Huijgen, P.E.M., Jakobs, C.A.J.M., van Geijn, H., von Blomberg-van der Flier, B.M.E.   +5 more
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Inhibition of Protein S by Autoantibodies in Patients with Acquired Protein S Deficiency

Thrombosis and Haemostasis, 1996
SummaryThis study was undertaken to analyze antibodies to protein S (PS) in patients with an acquired PS deficiency. Plasma from symptomatic patients with acquired (n = 14) or congenital (n = 10) PS deficiency and 10 healthy donors was screened for PS antibodies by immunoblotting and for anti-phospholipid antibodies.
SORICE, Maurizio, P. Arcieri, T. Griggi, CIRCELLA, annapia, MISASI, Roberta, LENTI, Luisa, G. D. Di Nucci, G. Mariani   +7 more
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