Results 291 to 300 of about 1,074,296 (345)

Protein S deficiency: a clinical perspective

Haemophilia, 2008
Summary.  Protein S (PS) is an extensively studied protein with an important function in the down‐regulation of thrombin generation. Because of the presence of a pseudogene and two different forms of PS in plasma, a bound and a free form, it is one of the most difficult thrombophilias to study.
Ten Kate, M. K., Van der Meer, J.
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Protein C and S Deficiency

Seminars in Thrombosis and Hemostasis, 1999
Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization.
F A, Nizzi, H S, Kaplan
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Protein S deficiency in pregnancy

American Journal of Obstetrics and Gynecology, 1986
The case of a primigravid patient with protein S deficiency, a rare disorder resulting in recurrent venous thrombosis, was managed with prophylactic heparin therapy and elective pregnancy termination. Although rarely diagnosed, protein S deficiency may become more commonly identified with wider application of protein S assays.
P G, Rose, G F, Essig, P S, Vaccaro, J T, Brandt   +3 more
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Protein S mRNA in Patients with Protein S Deficiency

Thrombosis and Haemostasis, 1995
SummaryA protein S gene polymorphism, detectable by restriction analysis (BstXI) of amplified exonic sequences (exon 15), was studied in seven Italian families with protein S deficiency. In the 17 individuals heterozygous for the polymorphism the study was extended to platelet mRNA through reverse transcription, amplification and densitometric analysis.
SACCHI E, PINOTTI, Mirko, MARCHETTI, Giovanna, MERATI G, TAGLIABUE L, MANNUCCI PM, BERNARDI, Francesco   +6 more
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Acquired protein S deficiency

The Clinical Investigator, 1992
Hereditary deficiencies of coagulation inhibitors like antithrombin III, protein C and protein S lead to an enhanced incidence of thromboembolic complications. Recently, acquired deficiencies of protein S were described in several disease states in which thromboembolic complications frequently occur. These acquired protein S deficiencies reach--in part-
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Hereditary Protein S Deficiency

Pathophysiology of Haemostasis and Thrombosis, 1985
Protein S is a vitamin K-dependent plasma protein that serves as a cofactor of activated protein C (APC) in its inhibitory action on activated factor V and factor VIII and in its stimulation of fibrinolytic activity. In plasma, part of the protein S is complexed with the C4b-binding protein. Only the free protein S has APC cofactor activity.
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Arterial thrombosis and protein S deficiency

The Journal of Pediatrics, 1992
A previously healthy boy had progressive painful discoloration of the lower extremities and was treated with exchange transfusion and anticoagulation, which were unsuccessful in arresting pedal ischemia; amputation of all of the child's toes was required. Studies of the patient and his parents resulted in a diagnosis of inherited protein S deficiency.
I N, Horowitz, A G, Galvis, E D, Gomperts   +2 more
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Moyamoya syndrome with protein S deficiency

European Journal of Paediatric Neurology, 2000
Moyamoya disease is a cerebrovascular disease with progressive occlusion of both internal carotid arteries and of their branches and formation of a new vascular network at the base of the brain. Because of the angiographic appearance, it is named as moyamoya.
D, Akgün, S, YiLmaz, N, Senbil, B, Aslan, Y Y, Gürer   +4 more
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Hereditary Protein S Deficiency: Clinical Manifestations

Annals of Internal Medicine, 1987
To analyze the clinical manifestations of protein S deficiency, we evaluated 136 members of 12 families with the disorder. Seventy-one persons were found to be heterozygous for protein S deficiency, which is inherited as an autosomal dominant trait. Venous thrombotic events occurred in 39 patients (55%) and were recurrent in 77%.
L, Engesser, A W, Broekmans, E, Briët, E J, Brommer, R M, Bertina   +4 more
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Serendipitous Diagnosis of Protein S Deficiency

Journal of Periodontology, 2002
A 46‐year‐old male sought periodontal care for a swelling on his right mandibular gingiva. An excisional biopsy revealed a well‐differentiated squamous cell carcinoma. Surgical treatment consisted of a right segmental mandibulectomy with ipsilateral right neck dissection and fibular free flap reconstruction.
A, Aguirre, J L, Tapia, S, Ciancio, J, Coniglio   +3 more
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