Results 301 to 310 of about 1,074,296 (345)
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Protein S deficiency: imaging findings.
American Journal of Roentgenology, 1993Protein S deficiency is an autosomal-dominant inherited disorder of coagulation associated with spontaneous and recurrent venous thrombosis. Approximately 5% of patients with deep venous thrombosis of the lower extremities who are less than 45 years old have a deficiency of protein S.
J P, Earls +3 more
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Analysis of the Protein S Gene in Protein S Deficiency
2003Protein S (PS) is a 71-kDa vitamin K-dependent glycoprotein first identified in human plasma by DiScipio and colleagues in 1977 (1), a year after the discovery of the anticoagulant protein C (PC) (2,3). A few years later, Walker demonstrated that PS acts as a cofactor for activated protein C (APC) in the proteolytic inactivation of the procoagulant ...
N, Sala, Y, Espinosa-Parrilla
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Severe Protein S Deficiency in a Newborn
Pediatrics, 1992Protein S is a vitamin K-dependent glycoprotein which acts as a cofactor for the anticoagulant activity of protein C.1,2 With production under autosomal control, heterozygotes produce half-normal levels and thrombotic disease may develop.3-6 Although thromboses occur primarily in adults, there are isolated reports of their occurrence in affected ...
C H, Pegelow +3 more
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Behçet Syndrome Associated with Protein S Deficiency
Thrombosis and Haemostasis, 1992SummaryBeçget syndrome is a multisystem disorder characterized by ocular, mucocutaneous, articular, gastrointestinal and neurologic abnormalities. We report here an unusual case of Beçget syndrome, characterized by the importance of the thrombotic events(7 phlebitis of both legs and resection of two toes).
O, Chafa +6 more
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Laboratory Diagnosis of Inherited Protein S Deficiency
American Journal of Clinical Pathology, 1990The authors investigated assays for free protein S (ProS) antigen, total ProS antigen, and ProS crossed immunoelectrophoresis (CIEP) in the diagnosis of type 1 inherited ProS deficiency. Accurate measurement of the hemostatically important free ProS required showing that, on each specimen, precipitation of the C4b-binding protein (C4b-BP)/protein S ...
J R, Edson, J M, Vogt, D A, Huesman
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Hereditary protein S deficiency
2020Venous thrombosis is a multifactorial disease, that genetic and environmental factors play a part. Especially, in the patients who have experienced recurrent venous thromboembolisms (VTE) and also in their relatives with similar clinical features; it might present as a congenital coagulation inhibitor deficiency that can cause hereditary thrombotic ...
Dremirağ M.K. +3 more
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2018
This chapter discusses the pathophysiology, inheritance, and epidemiology of protein C and protein S deficiencies. The chapter discusses the impact of protein C and protein S deficiencies on pregnant women and details suggested medical and anesthetic management of affected individuals.
James P. R. Brown, Joanne Douglas
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This chapter discusses the pathophysiology, inheritance, and epidemiology of protein C and protein S deficiencies. The chapter discusses the impact of protein C and protein S deficiencies on pregnant women and details suggested medical and anesthetic management of affected individuals.
James P. R. Brown, Joanne Douglas
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Protein C and protein S deficiencies.
Seminars in hematology, 1997The protein C (PC) pathway, with its cofactor protein S (PS), is an important natural antithrombotic mechanism. Both PC and PS deficiencies have been implicated in thrombophilia. The molecular basis for hereditary PC and PS deficiencies is highly heterogeneous, with a large spectrum of mutations that have various effects on the expression of the ...
M, Aiach +5 more
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Dysfunctional protein S deficiency
1989We describe a previously unreported defect of protein S characterized by low levels of cofactor activity for activated protein C contrasting with low normal levels of total and free protein S antigen. The distribution of protein S between the free form and the form complexed with the complement component C4b-binding protein was normal on two ...
P. M. Mannucci +4 more
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly