Results 131 to 140 of about 1,038,800 (260)

Protein Secondary Structure Prediction Using Soft Computing Techniques. [PDF]

Biotechnol Appl Biochem
K S, Yaduvanshi P, Masood S, Singh P.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

DSSP 4: FAIR annotation of protein secondary structure. [PDF]

Protein Sci
Hekkelman ML, Salmoral DÁ, Perrakis A, Joosten RP.   +3 more
europepmc   +1 more source

Deep Ensemble Learning with Atrous Spatial Pyramid Networks for Protein Secondary Structure Prediction. [PDF]

Biomolecules, 2022
Guo Y, Wu J, Ma H, Wang S, Huang J.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Combining knowledge distillation and neural networks to predict protein secondary structure. [PDF]

Sci Rep
Zhao L, Li J, Zhang B, Jiang X.
europepmc   +1 more source

Lightweight ProteinUnet2 network for protein secondary structure prediction: a step towards proper evaluation. [PDF]

BMC Bioinformatics, 2022
Stapor K, Kotowski K, Smolarczyk T, Roterman I.   +3 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Enhancing 3D Printability of Black Soldier Fly Protein-Based Composite Gels by Incorporating Grape Seed Anthocyanin: Rheology, Water State, Protein Secondary Structure, and Microstructure. [PDF]

Materials (Basel)
Deng W, Liao J, Guo C.
europepmc   +1 more source

Evaluation of key aroma compounds and protein secondary structure in the roasted Tan mutton during the traditional charcoal process. [PDF]

Front Nutr, 2022
Wang YR, Wang SL, Luo RM.
europepmc   +1 more source