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Prediction of super-secondary structure in proteins
Nature, 1983Various methods for the prediction of secondary structure from amino acid sequence can consistently achieve on average 60% accuracy when tested for several proteins. Improvement on this value has proved difficult, despite increasing the size of the data set and refining predictive techniques.
W R, Taylor, J M, Thornton
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Improving Protein Secondary-Structure Prediction by Predicting Ends of Secondary-Structure Segments
2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 2005Motivated by known preferences for certain amino acids in positions around a-helices, we developed neural network-based predictors of both N and C a-helix ends, which achieved about 88% accuracy. We applied a similar approach for predicting the ends of three types of secondary structure segments.
Uros Midic +2 more
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A Grid-Enabled Protein Secondary Structure Predictor
IEEE Transactions on Nanobioscience, 2007We present an integrated Grid system for the prediction of protein secondary structures, based on the frequent automatic update of proteins in the training set. The predictor model is based on a feed-forward multilayer perceptron (MLP) neural network which is trained with the back-propagation algorithm; the design reuses existing legacy software and ...
M. MIRTO +4 more
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Secondary structure prediction and protein design.
Biochemical Society symposium, 1990For non-homologous proteins, and after cross-validation, the methods reviewed in this article exhibit a probability index (percentage of correctly predicted residues per predicted residues) of 59-65.5% according to the methods employed with a standard deviation of 7% for three conformational states: alpha-helix, beta-strand and coil.
Garnier, Jean +3 more
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Structural analysis of protein Secondary Structure by GHT.
2012Structural biology is a branch of life science concerned with the study of the structure of biological macromolecules like proteins. The structure of a protein gives much more insight in its functions than that of its amino acid sequence. Protein structure comparison is important for understanding the evolutionary relationships among proteins ...
Cantoni, Virginio +3 more
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