Results 101 to 110 of about 2,206,167 (301)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Mechanism of Gene Amplification via Yeast Autonomously Replicating Sequences

The Scientific World Journal, 2015
The present investigation was aimed at understanding the molecular mechanism of gene amplification. Interplay of fragile sites in promoting gene amplification was also elucidated.
Shelly Sehgal, Sanjana Kaul, M. K. Dhar
doaj   +1 more source

Protein sequences bound to mineral surfaces persist into deep time

eLife, 2016
Proteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving the protein sequence in ostrich (Struthionidae) eggshell ...
B. Demarchi, Shaun A. Hall, T. Roncal-Herrero, C. Freeman, Jos Woolley, Molly K. Crisp, Julie Wilson, A. Fotakis, R. Fischer, B. Kessler, Rosa Rakownikow Jersie-Christensen, J. Olsen, James Haile, Jessica E Thomas, C. Marean, J. Parkington, Samantha Presslee, J. Lee-Thorp, P. Ditchfield, J. Hamilton, M. Ward, Chunting Wang, M. Shaw, T. Harrison, M. Domínguez‐Rodrigo, R. Macphee, A. Kwekason, M. Ecker, L. Kolska Horwitz, M. Chazan, R. Kröger, J. Thomas-Oates, J. Harding, E. Cappellini, K. Penkman, M. Collins   +35 more
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

3D structure prediction of replication factor C subunits (RFC) and their interactome in Arabidopsis thaliana [PDF]

Network Biology, 2013
DNA stress can causes potentially spontaneous genome damage during DNA replication process. Proteins involved in this process are DNA-dependent ATPases, required for replication and repair.
Mohamed Ragab Abdel Gawwad, Jasmin Sutkovic, Emina Zahirovic, et al.   +2 more
doaj  

Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions

BMC Genomics, 2006
Background DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions. Results Here we studied using bioinformatics tools several properties of triplex target sequences
Dopazo Joaquin, Vaquerizas Juan, Goñi Josep, Orozco Modesto   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Detection of Trypanosoma cruzi DNA within murine cardiac tissue sections by in situ polymerase chain reaction

Memorias do Instituto Oswaldo Cruz, 2003
The use of in situ techniques to detect DNA and RNA sequences has proven to be an invaluable technique with paraffin-embedded tissue. Advances in non-radioactive detection systems have further made these procedures shorter and safer.
Joshua E Lane, Rodrigo Ribeiro-Rodrigues, Danyvid Olivares-Villagómez, Cindy L Vnencak-Jones, Thomas L McCurley, Clint E Carter   +5 more
doaj   +1 more source