Results 81 to 90 of about 1,706,932 (293)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Improving prediction performance of general protein language model by domain-adaptive pretraining on DNA-binding protein

Nature Communications
DNA-protein interactions exert the fundamental structure of many pivotal biological processes, such as DNA replication, transcription, and gene regulation. However, accurate and efficient computational methods for identifying these interactions are still
Wenwu Zeng, Yutao Dou, Liangrui Pan, Liwen Xu, Shaoliang Peng   +4 more
doaj   +1 more source

Isolation of Potato Genes That Are Induced During an Early Stage of the Hypersensitive Response to Phytophthora infestans

Molecular Plant-Microbe Interactions, 1999
Suppression subtractive hybridization (SSH) was used to generate a cDNA library enriched for sequences induced in a late-blight-resistant potato cultivar undergoing the hypersensitive response (HR).
Paul R. J. Birch, Anna O. Avrova, James M. Duncan, Gary D. Lyon, Rachel L. Toth   +4 more
doaj   +1 more source

Annotation, submission and screening of repetitive elements in Repbase: RepbaseSubmitter and Censor [PDF]

, 2006
Background Repbase is a reference database of eukaryotic repetitive DNA, which includes prototypic sequences of repeats and basic information described in annotations.
Oleksiy Kohany, Andrew J Gentles, Lukasz Hankus, Jerzy Jurka   +3 more
core   +1 more source

A Model of Sequence-Dependent Protein Diffusion Along DNA [PDF]

Journal of Biological Physics, 2004
We introduce a probabilistic model for protein sliding motion along DNA during the search of a target sequence. The model accounts for possible effects due to sequence-dependent interaction between the nonspecific DNA and the protein. As an example, we focus on T7 RNA-polymerase and exploit the available information about its interaction at the ...
Barbi, Maria, Place, Christophe, Popkov, Vladislav, Salerno, Mario   +3 more
openaire   +5 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gene Unprediction with Spurio: A tool to identify spurious protein sequences [version 1; referees: 2 approved]

F1000Research, 2018
We now have access to the sequences of tens of millions of proteins. These protein sequences are essential for modern molecular biology and computational biology.
Wolfram Höps, Matt Jeffryes, Alex Bateman   +2 more
doaj   +1 more source

Characteristic Length Scale of Electric Transport Properties of Genomes

, 2005
A tight-binding model together with a novel statistical method are used to investigate the relation between the sequence-dependent electric transport properties and the sequences of protein-coding regions of complete genomes.
C. T. Shih, D. Holste, S. R. Rajski, W. Li   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source