Results 61 to 70 of about 7,767,567 (301)

Genomic Diversity of CRESS DNA Viruses in the Eukaryotic Virome of Swine Feces

Microorganisms, 2021
Replication-associated protein (Rep)-encoding single-stranded DNA (CRESS DNA) viruses are a diverse group of viruses, and their persistence in the environment has been studied for over a decade.
Enikő Fehér, Eszter Mihalov-Kovács, Eszter Kaszab, Yashpal S. Malik, Szilvia Marton, Krisztián Bányai   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs [PDF]

, 2010
Background: Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask of ...
García Alcalde, Fernando, Blanco Morón, Armando, Armando Blanco, Blanco, A., Blanco Armando, Shepherd Adrian J, Shepherd, Adrian J., Garcia-Alcalde Fernando, Garcia-Alcalde, F., Adrian J Shepherd, Fernando Garcia-Alcalde   +10 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. [PDF]

PLoS ONE, 2011
We have investigated a region of ∼310 kb of genomic DNA within polytene chromosome subdivisions 72A to 72D of Drosophila melanogaster. This region includes 57 predicted protein-coding genes.
Monica T Cooper, James A Kennison
doaj   +1 more source

Identification of protein coding genes in genomes with statistical functions based on the circular code [PDF]

, 2002
A new statistical approach using functions based on the circular code classifies correctly more than 93 % of bases in protein (coding) genes and non-coding genes of human sequences. Based on this statistical study, a research software called "Analysis of
Lacan, Jérôme, Didier G. Arquès A, Jérôme Lacan B, Christian J. Michel C, Arquès, Didier, Michel, Christian   +5 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2

BMC Research Notes, 2021
Objective This study describes the occurrence of a silent mutation in the RNA binding domain of nucleocapsid phosphoprotein (N protein) coding gene from SARS-CoV-2 that may consequence to a missense mutation by onset of another single nucleotide mutation.
Reza Zolfaghari Emameh, Mahyar Eftekhari, Hassan Nosrati, Jalal Heshmatnia, Reza Falak   +4 more
doaj   +1 more source

Dynamic distribution of SeqA protein across the chromosome of Escherichia coli K-12 [PDF]

, 2010
The bacterial SeqA protein binds to hemi-methylated GATC sequences that arise in newly synthesized DNA upon passage of the replication machinery. In Escherichia coli K-12, the single replication origin oriC is a well-characterized target for SeqA, which ...
Stephen J. W. Busby, Nigel P. Dyer, Sascha Ott, Sánchez-Romero, María Antonia, Dyer, NP, Millard, AD, Sanchez-Romero, MA, María Antonia Sánchez-Romero, Busby, Stephen; id_orcid, Ott, S, Grainger, David, Dyer, Nigel, Millard, Andrew D., David C. Grainger, Ott, Sascha, Andrew D. Millard, Busby, S. (Stephen), Grainger, David C.   +17 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source