Results 41 to 50 of about 7,767,567 (301)
Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability
Microorganisms, 2020 G-rich DNA repeats that can form G-quadruplex structures are prevalent in bacterial genomes and are frequently associated with regulatory regions of genes involved in virulence, antigenic variation, and antibiotic resistance.
Virali J. Parekh +5 more
doaj +1 more source
Large scale hierarchical clustering of protein sequences [PDF]
, 2005 Krause A, Stoye J, Vingron M. Large scale hierarchical clustering of protein sequences. BMC Bioinformatics. 2005;6(1): 15.Background: Searching a biological sequence database with a query sequence looking for homologues has become a routine operation in ...
Stoye Jens +11 more
core +1 more source
DNA sequences classification and computation scheme based on the symmetry principle [PDF]
, 2009 The DNA sequences containing multifarious novel symmetrical structure frequently play crucial role in how genomes work. Here we present a new scheme for understanding the structural features and potential mathematical rules of symmetrical DNA sequences ...
Xiao-Gang Song, Wen-Yuan Qiu
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Hands-On Assembly of DNA Sequencing Reads as a Gateway to Bioinformatics
Journal of Microbiology & Biology Education, 2017 The scale of genomic sequencing data and the complexity of bioinformatic algorithms make it difficult for students to develop a concrete understanding of assembling complete genomes from millions of short DNA sequences.
Paul A. Jensen
doaj +1 more source
Codon optimization with deep learning to enhance protein expression
Scientific Reports, 2020 Heterologous expression is the main approach for recombinant protein production ingenetic synthesis, for which codon optimization is necessary. The existing optimization methods are based on biological indexes.
Hongguang Fu +8 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BioVR: a platform for virtual reality assisted biological data integration and visualization
BMC Bioinformatics, 2019 Background Functional characterization of single nucleotide variants (SNVs) involves two steps, the first step is to convert DNA to protein and the second step is to visualize protein sequences with their structures.
Jimmy F. Zhang +3 more
doaj +1 more source
Random-PE: an efficient integration of random sequences into mammalian genome by prime editing
Molecular Biomedicine, 2021 Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks or donor templates.
Yaoge Jiao +7 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source