Results 21 to 30 of about 2,206,167 (301)
Codon preference and its use in identifying protein coding regions in long DNA sequences
Nucleic Acids Research, 1982 A D Mclachlan, R Staden
exaly +2 more sources
Nucleic Acids Research, 2021 In order to uncover the meanings of ‘book of life’, 155 different biological language models (BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are able to extract the linguistic properties of ‘book of life’.
Hongliang Li, Yihe Pang, Bin Liu
semanticscholar +1 more source
Extended many-item similarity indices for sets of nucleotide and protein sequences
Computational and Structural Biotechnology Journal, 2021 Quantification of similarities between protein sequences or DNA/RNA strands is a (sub-)task that is ubiquitously present in bioinformatics workflows, and is usually accomplished by pairwise comparisons of sequences, utilizing simple (e.g.
Dávid Bajusz +3 more
doaj +1 more source
More-SPEED: Enhancing Protein Activity Prediction from DNA Sequences
Iraqi Journal for Computer Science and Mathematics, 2023 This work presents More-SPEED, a novel model for accurately predicting protein activity while minimizing computational demands. Leveraging optimized structures and data preprocessing techniques, More-SPEED achieves high accuracy in protein activity ...
Samaher Al-Janabi, Zena A. Kadhuim
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2007 Rafael Giraldo
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Methods for comparing a DNA sequence with a protein sequence [PDF]
Bioinformatics, 1996 We describe two methods for constructing an optimal global alignment of, and an optimal local alignment between, a DNA sequence and a protein sequence. The alignment model of the methods addresses the problems of frameshifts and introns in the DNA sequence. The methods require computer memory proportional to the sequence lengths, so they can rigorously
Huang, Xiaoqiu, Zhang, Jinghui
openaire +3 more sources
Nature Biotechnology, 2021 The targeted deletion, replacement, integration or inversion of genomic sequences could be used to study or treat human genetic diseases, but existing methods typically require double-strand DNA breaks (DSBs) that lead to undesired consequences ...
Andrew V. Anzalone +8 more
semanticscholar +1 more source
Predicting target DNA sequences of DNA-binding proteins based on unbound structures. [PDF]
PLoS ONE, 2012 DNA-binding proteins such as transcription factors use DNA-binding domains (DBDs) to bind to specific sequences in the genome to initiate many important biological functions.
Chien-Yu Chen +5 more
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Cell Systems, 2020 SUMMARY Engineering gene and protein sequences with defined functional properties is a major goal of synthetic biology. Deep neural network models, together with gradient ascent-style optimization, show promise for sequence design.
Johannes Linder +3 more
semanticscholar +1 more source
A linear model for transcription factor binding affinity prediction in protein binding microarrays. [PDF]
PLoS ONE, 2011 Protein binding microarrays (PBM) are a high throughput technology used to characterize protein-DNA binding. The arrays measure a protein's affinity toward thousands of double-stranded DNA sequences at once, producing a comprehensive binding specificity ...
Matti Annala +3 more
doaj +1 more source