Results 51 to 60 of about 1,223,016 (311)
H-NS can facilitate specific DNA-binding by RNA polymerase in AT-rich gene regulatory regions.
PLoS Genetics, 2013 Extremely AT-rich DNA sequences present a challenging template for specific recognition by RNA polymerase. In bacteria, this is because the promoter -10 hexamer, the major DNA element recognised by RNA polymerase, is itself AT-rich.
Shivani S Singh, David C Grainger
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Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability
Microorganisms, 2020 G-rich DNA repeats that can form G-quadruplex structures are prevalent in bacterial genomes and are frequently associated with regulatory regions of genes involved in virulence, antigenic variation, and antibiotic resistance.
Virali J. Parekh +5 more
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Plants, 2022 The studies on the prevalence and genetic diversity of begomoviruses in Saudi Arabia are minimal. In this study, field-grown symptomatic tomato and muskmelon plants were collected, and initially, begomovirus infection was confirmed by the core coat ...
Khalid A. AlHudaib +5 more
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Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]
, 2006 Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core +1 more source
DNA sequences classification and computation scheme based on the symmetry principle [PDF]
, 2009 The DNA sequences containing multifarious novel symmetrical structure frequently play crucial role in how genomes work. Here we present a new scheme for understanding the structural features and potential mathematical rules of symmetrical DNA sequences ...
Xiao-Gang Song, Wen-Yuan Qiu
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Hands-On Assembly of DNA Sequencing Reads as a Gateway to Bioinformatics
Journal of Microbiology & Biology Education, 2017 The scale of genomic sequencing data and the complexity of bioinformatic algorithms make it difficult for students to develop a concrete understanding of assembling complete genomes from millions of short DNA sequences.
Paul A. Jensen
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Random-PE: an efficient integration of random sequences into mammalian genome by prime editing
Molecular Biomedicine, 2021 Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks or donor templates.
Yaoge Jiao +7 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
BioVR: a platform for virtual reality assisted biological data integration and visualization
BMC Bioinformatics, 2019 Background Functional characterization of single nucleotide variants (SNVs) involves two steps, the first step is to convert DNA to protein and the second step is to visualize protein sequences with their structures.
Jimmy F. Zhang +3 more
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