Results 51 to 60 of about 1,706,932 (293)
Sequence specific interaction of the chromosomal proteins with DNA [PDF]
Nucleic Acids Research, 1977 Calf thymus chromatin was partially deproteinized by 0.6-1 M NaCl extraction. From the shape of the temperature derivative plot of its melting curve, the DNA in each chromatin was resolved into regions of exposed DNA, and DNA still complexed with proteins.
D, Tuan, C, Chetsanga, P M, Doty
openaire +2 more sources
Hands-On Assembly of DNA Sequencing Reads as a Gateway to Bioinformatics
Journal of Microbiology & Biology Education, 2017 The scale of genomic sequencing data and the complexity of bioinformatic algorithms make it difficult for students to develop a concrete understanding of assembling complete genomes from millions of short DNA sequences.
Paul A. Jensen
doaj +1 more source
Codon optimization with deep learning to enhance protein expression
Scientific Reports, 2020 Heterologous expression is the main approach for recombinant protein production ingenetic synthesis, for which codon optimization is necessary. The existing optimization methods are based on biological indexes.
Hongguang Fu +8 more
doaj +1 more source
Random-PE: an efficient integration of random sequences into mammalian genome by prime editing
Molecular Biomedicine, 2021 Prime editing (PE) enables efficiently targeted introduction of multiple types of small-sized genetic change without requiring double-strand breaks or donor templates.
Yaoge Jiao +7 more
doaj +1 more source
p63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca [PDF]
, 2009 Genes of the p53 family are known to be critical regulators of the cell cycle. They have already been established as possible biomarkers. Elaborate regulation mechanisms result in numerous cDNA and protein isoforms being expressed from each gene of the ...
Baričević, Ana +6 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider +4 more
wiley +1 more source
BioVR: a platform for virtual reality assisted biological data integration and visualization
BMC Bioinformatics, 2019 Background Functional characterization of single nucleotide variants (SNVs) involves two steps, the first step is to convert DNA to protein and the second step is to visualize protein sequences with their structures.
Jimmy F. Zhang +3 more
doaj +1 more source
Finding errors in DNA sequences [PDF]
, 1992 An algorithm is described that can detect certain errors within coding regions of DNA sequences. The algorithm is based on the idea that an insertion or deletion error within a coding sequence would interrupt the reading frame and cause the correct ...
Posfai, J., Roberts, R. J.
core +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
A novel mathematical tool for generating highly conserved protein domain via different organismal genomic landscapes [PDF]
, 2010 Darwinian evolution hypothesizes that a short stretch of DNA was first constructed and then it expanded to give rise to a long strand. This long strand then produced a mix of exons, introns and repetitive DNA sequence.
Arunava Goswami +3 more
core +2 more sources