Results 51 to 60 of about 7,767,567 (301)

Benchmarking tools for the alignment of functional noncoding DNA [PDF]

, 2004
Pollard DA, Bergman CM, Stoye J, Celniker SE, Eisen MB. Benchmarking tools for the alignment of functional noncoding DNA. BMC Bioinformatics. 2004;5(1): 6.Background: Numerous tools have been developed to align genomic sequences.
Celniker SE, Eisen MB, MB Eisen, Stoye J, Bergman CM, Celniker, Susan E., Bergman, Casey M., SE Celniker, Pollard, Daniel A., Pollard DA, CM Bergman, Eisen, Michael B., J Stoye, Stoye, Jens, Stoye, Jens ; https://orcid.org/, DA Pollard, Michael B Eisen, Daniel A Pollard, Casey M Bergman, Jens Stoye, Susan E Celniker   +20 more
core   +5 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Generation of siRNAs by T-DNA Sequences Does Not Require Active Transcription or Homology to Sequences in the Plant

Molecular Plant-Microbe Interactions, 2002
Delivery into plants of T-DNAs containing promoter, terminator, or coding sequences generated small interfering RNAs (siRNAs) specific to each type of sequence.
Tomas Canto, Fabrizio Cillo, Peter Palukaitis   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Computational analysis of promoters and DNA-protein interactions [PDF]

, 2009
The investigation of promoter activity and DNA-protein interactions is very important for understanding many crucial cellular processes, including transcription, recombination and replication.
Tomovic, Andrija
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Diversity and recombination of dispersed ribosomal DNA and protein coding genes in microsporidia. [PDF]

PLoS ONE, 2013
Microsporidian strains are usually classified on the basis of their ribosomal DNA (rDNA) sequences. Although rDNA occurs as multiple copies, in most non-microsporidian species copies within a genome occur as tandem arrays and are homogenised by concerted
Joseph Edward Ironside
doaj   +1 more source

The Sequence Manipulation Suite: JavaScript Programs for Analyzing and Formatting Protein and DNA Sequences [PDF]

BioTechniques, 2000
JavaScript is an object-based scripting language that can be interpreted by most commonly used Web browsers, including Netscape® Navigator® and Internet Explorer®. In conjunction with HTML form elements, JavaScript can be used to make flexible and easy-to-use applications that can be accessed by anyone connected to the Internet (3).
openaire   +4 more sources

Investigations into the molecular effects of single nucleotide polymorphism [PDF]

, 2000
Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Lohrer, Horst D., Tangen, Uwe, Lohrer, H.D., Tangen, U.   +3 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source