Results 61 to 70 of about 6,859,921 (298)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The CATH database: an extended protein family resource for structural and functional genomics [PDF]

, 2003
The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383 superfamilies and 3285 sequence families.
Pearl, F.M.G., Martin, Nigel, Bennett, C.F., Harrison, A.P., Sillitoe, I., Shepherd, Adrian J., Thornton, Janet M., Bray, J.E., Orengo, C.A.   +8 more
core   +1 more source

Virus Pop—Expanding Viral Databases by Protein Sequence Simulation

Viruses, 2023
The improvement of our knowledge of the virosphere, which includes unknown viruses, is a key area in virology. Metagenomics tools, which perform taxonomic assignation from high throughput sequencing datasets, are generally evaluated with datasets derived
Julia Kende, Massimiliano Bonomi, Sarah Temmam, Béatrice Regnault, Philippe Pérot, Marc Eloit, Thomas Bigot   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

TAFPred: Torsion Angle Fluctuations Prediction from Protein Sequences

Biology, 2023
Protein molecules show varying degrees of flexibility throughout their three-dimensional structures. The flexibility is determined by the fluctuations in torsion angles, specifically phi (φ) and psi (ψ), which define the protein backbone.
Md Wasi Ul Kabir, Duaa Mohammad Alawad, Avdesh Mishra, Md Tamjidul Hoque   +3 more
doaj   +1 more source

PoET: A generative model of protein families as sequences-of-sequences

Advances in Neural Information Processing Systems 36, 2023
Generative protein language models are a natural way to design new proteins with desired functions. However, current models are either difficult to direct to produce a protein from a specific family of interest, or must be trained on a large multiple sequence alignment (MSA) from the specific family of interest, making them unable to benefit from ...
Timothy F. Truong Jr., Tristan Bepler
openaire   +4 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis [PDF]

, 2013
2A oligopeptide sequences (“2As”) mediate a cotranslational recoding event termed “ribosome skipping.” Previously we demonstrated the activity of 2As (and “2A-like sequences”) within a wide range of animal RNA virus genomes and non-long terminal repeat ...
Sukhodub, Andriy, Ryan, MD, De Felipe, Pablo, Ruan, L, Odon, Valerie Marie Nathalie, de Felipe, P, Sukhodub, A, Luke, Garry Alec, Ruan, Lin, Escuin-Ordinas, H, Roulston, Claire, Odon, V, Ryan, Martin Denis, Brown, JD, Roulston, C, Brown, Jeremy, Luke, GA, Escuin, Helena, Ryan, Martin Denis; id_orcid   +18 more
core   +1 more source

DCGR: feature extractions from protein sequences based on CGR via remodeling multiple information

BMC Bioinformatics, 2019
Background Protein feature extraction plays an important role in the areas of similarity analysis of protein sequences and prediction of protein structures, functions and interactions.
Zengchao Mu, Ting Yu, Enfeng Qi, Juntao Liu, Guojun Li   +4 more
doaj   +1 more source