Results 41 to 50 of about 6,859,921 (298)

Variable selection from a feature representing protein sequences: a case of classification on bacterial type IV secreted effectors

BMC Bioinformatics, 2020
Background Classification of certain proteins with specific functions is momentous for biological research. Encoding approaches of protein sequences for feature extraction play an important role in protein classification.
Jian Zhang, Lixin Lv, Donglei Lu, Denan Kong, Mohammed Abdoh Ali Al-Alashaari, Xudong Zhao   +5 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]

, 2012
Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core   +1 more source

PRO-GO: Reference-Guided Protein Sequence Generation Using Gene Ontology Terms

IEEE Access
Protein sequence generation models aim to produce valid protein candidates on demand, however, controllably generating protein sequences with specified target functionalities remains difficult.
Darren Tan, Ian McLoughlin, Aik Beng Ng, Zhengkui Wang, Abraham C. Stern, Simon See   +5 more
doaj   +1 more source

WildSpan: mining structured motifs from protein sequences

Algorithms for Molecular Biology, 2011
Background Automatic extraction of motifs from biological sequences is an important research problem in study of molecular biology. For proteins, it is desired to discover sequence motifs containing a large number of wildcard symbols, as the residues ...
Chen Chien-Yu, Hsu Chen-Ming, Liu Baw-Jhiune   +2 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Protein sequence randomness and sequence/structure correlations

Biophysical Journal, 1995
We investigated protein sequence/structure correlation by constructing a space of protein sequences, based on methods developed previously for constructing a space of protein structures. The space is constructed by using a representation of the amino acids as vectors of 10 property factors that encode almost all of their physical properties.
Rahman, R.S., Rackovsky, S.
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Identification of protein coding genes in genomes with statistical functions based on the circular code [PDF]

, 2002
A new statistical approach using functions based on the circular code classifies correctly more than 93 % of bases in protein (coding) genes and non-coding genes of human sequences. Based on this statistical study, a research software called "Analysis of
Lacan, Jérôme, Didier G. Arquès A, Jérôme Lacan B, Christian J. Michel C, Arquès, Didier, Michel, Christian   +5 more
core   +1 more source

Detecting pore-lining regions in transmembrane protein sequences

BMC Bioinformatics, 2012
Background Alpha-helical transmembrane channel and transporter proteins play vital roles in a diverse range of essential biological processes and are crucial in facilitating the passage of ions and molecules across the lipid bilayer.
Nugent Timothy, Jones David T
doaj   +1 more source