Results 111 to 120 of about 142,215 (332)
Environmental Toxicology and Chemistry, Volume 42, Issue 1, Page 71-87, January 2023., 2023 Abstract For the majority of developed adverse outcome pathways (AOPs), the taxonomic domain of applicability (tDOA) is typically narrowly defined with a single or a handful of species. Defining the tDOA of an AOP is critical for use in regulatory decision‐making, particularly when considering protection of untested species.
Marissa A. Jensen +2 more
wiley +1 more source
Mediators of Inflammation, 2014 Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many ...
Yanyan Yang +7 more
doaj +1 more source
Haematologica, 2010 The identification as cooperating targets of Proviral Integrations of Moloney virus in murine lymphomas suggested early on that PIM serine/threonine kinases play an important role in cancer biology.
Laurent Brault +5 more
doaj +1 more source
Phosphorylation of threonine and serine residues of native and partially dephosphorylated caseins by a rat liver cyclic AMP-insensitive protein kinase [PDF]
, 1979 D Deana, Flavio Meggio, Lorenzo A. Pinna
openalex +1 more source
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source
BMC GenomicsBackground Flowering time has an important effect on regional adaptation and yields for crops. The tyrosine kinase-like (TKL) gene family is widely existed and participates in many biological processes in plants.
Peisen S. Su +10 more
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Characterization of a Tomato Protein Kinase Gene Induced by Infection by Potato spindle tuber viroid
Molecular Plant-Microbe Interactions, 2000 Viroids—covalently closed, circular RNA molecules in the size range of 250 to 450 nucleotides—are the smallest known infectious agents and cause a number of diseases of crop plants.
Rosemarie W. Hammond, Yan Zhao
doaj +1 more source
Quantum walks and signal transduction pathways [PDF]
arXiv, 2012 Signal transduction pathways recover a crucial role in cellular processes: they represent a connection between environmental conditions and cellular reactions. There are many pathways and they all are related to create a network. But how can every protein find the right way more fast than possible? How can it find the right down-streaming kinase in the
arxiv
Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives
American Journal of Hematology, EarlyView.ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley +1 more source
Food Bioengineering, Volume 1, Issue 3-4, Page 224-232, December 2022., 2022 (a) Mannosyl compounds obtained from microbial fermentation exhibited immunomodulatory activities in the innate and adaptive immune systems. (b) The immunomodulatory activity of mannosyl compounds on RAW 264.7 cells mainly functioned through mitogen‐activated protein kinases and MyD88‐dependent signaling pathways.
Juanjuan Liu +5 more
wiley +1 more source