Breaking barriers: Smart vaccine platforms for cancer immunomodulation
Cancer Communications, EarlyView.Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari +11 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 1, Page 52-60, January 2023., 2023 Abstract MicroRNAs (miRNAs) exert critical effects in spinal cord injury (SCI). The miR‐33‐5p level is found to be lower in rats with SCI compared with that in control (untreated) and sham‐operated (laminectomy but no contusion) rats. Therefore, we investigated the biological functions of miR‐33‐5p and related mechanisms in SCI pathogenesis and ...
Zhe Li +2 more
wiley +1 more source
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo [PDF]
, 2000 Sean P. COLLINS +3 more
openalex +1 more source
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Cancer Communications, EarlyView.Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan +13 more
wiley +1 more source
Generation of a serine/threonine-protein kinase LATS1 gene-edited iPSC MUSIi012-A-3
Stem Cell Research, 2020 In mammals, there are a number of kinases, including serine/threonine-protein kinase LATS1, that act as a core kinase of the Hippo pathway and that negatively regulate the Hippo effector protein YAP and its paralog TAZ.
Chanchao Lorthongpanich +8 more
doaj
Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations [PDF]
arXivThe intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes constitute a conserved mechanism for self-regulation that dramatically impacts kinases' affinities for ...
arxiv
Receptor serine/threonine protein kinases in signalling: analysis of the erecta receptor‐like kinase of Arabidopsis thaliana [PDF]
, 2001 Kevin A. Lease +4 more
openalex +1 more source
Molecule Generation for Target Protein Binding with Hierarchical Consistency Diffusion Model [PDF]
arXivEffective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models for 3D molecular generation, current methods often struggle with validity and reliability.
arxiv
A serine/threonine kinase p90rsk1 phosphorylates the anti‐proliferative protein Tob [PDF]
, 2001 Toru Suzuki +4 more
openalex +1 more source