Results 291 to 300 of about 142,215 (332)
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Identification and characterization of the serine/threonine protein kinases in Bifidobacterium
Archives of Microbiology, 2014Six genes encoding the bifidobacterial Hanks-type (eukaryote-like) serine/threonine protein kinases (STPK) were identified and classified. The genome of each bifidobacterial strain contains four conserved genes and one species-specific gene. Bifidobacterium longum and Bifidobacterium bifidum possess the unique gene found only in these species. The STPK
Natalia V. Zakharevich +5 more
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Synthetic sulfoglycolipids targeting the serine–threonine protein kinase Akt
Bioorganic & Medicinal Chemistry, 2016The serine-threonine protein kinase Akt, also known as protein kinase B, is a key component of the phosphoinositide 3-kinase (PI3K)-Akt-mTOR axis. Deregulated activation of this pathway is frequent in human tumors and Akt-dependent signaling appears to be critical in cell survival.
COSTA, BARBARA SIMONA +14 more
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Protein-serine/threonine/tyrosine kinases in bacterial signaling and regulation
FEMS Microbiology Letters, 2013In this review, we address some recent developments in the field of bacterial protein phosphorylation, focusing specifically on serine/threonine and tyrosine kinases. We present an overview of recent studies outlining the scope of physiological processes that are regulated by phosphorylation, ranging from cell cycle, growth, cell morphology, to ...
Ivan Mijakovic +8 more
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Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt
Science, 1997A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70 S6K ...
Morris J. Birnbaum +8 more
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PLANT PROTEIN SERINE/THREONINE KINASES: Classification and Functions
Annual Review of Plant Physiology and Plant Molecular Biology, 1999▪ Abstract The first plant protein kinase sequences were reported as recently as 1989, but by mid-1998 there were more than 500, including 175 in Arabidopsis thaliana alone. Despite this impressive pace of discovery, progress in understanding the detailed functions of protein kinases in plants has been slower. Protein serine/threonine kinases from A.
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A brain serine/threonine protein kinase activated by Cdc42 and Rac1
Nature, 1994A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase ...
Manser, E. +4 more
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PkpA, a novel Phycomyces blakesleeanus serine/threonine protein kinase
Current Genetics, 1995This work reports the cloning and sequencing of pkpA, a gene of the filamentous fungus Phycomyces blakesleeanus, whose expression seems to be coupled to vegetative growth. This gene encodes a putative serine/threonine-specific protein kinase, whose sequence is related to that of the yeast protein STE20, involved in pheromone-response pathways, and to a
Santiago Torres-Martínez +2 more
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RAF protein-serine/threonine kinases: Structure and regulation
Biochemical and Biophysical Research Communications, 2010A-RAF, B-RAF, and C-RAF are a family of three protein-serine/threonine kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including apoptosis, cell cycle progression, differentiation, proliferation, and transformation to the cancerous state.
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Biochemical and Biophysical Research Communications, 1999
We report the molecular cloning and initial characterization of a novel fatty acid acylated serine/threonine protein kinase. The putative open reading frame is predicted to encode a 305 amino acid protein possessing a carboxy-terminal protein kinase domain and amino-terminal myristylation and palmitylation sites. The protein kinase has been accordingly
Bonnie Wu +7 more
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We report the molecular cloning and initial characterization of a novel fatty acid acylated serine/threonine protein kinase. The putative open reading frame is predicted to encode a 305 amino acid protein possessing a carboxy-terminal protein kinase domain and amino-terminal myristylation and palmitylation sites. The protein kinase has been accordingly
Bonnie Wu +7 more
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Inhibition of Eukaryote Serine/Threonine-Specific Protein Kinases by Piceatannol
Planta Medica, 1998The protein tyrosine kinase (PTK) inhibitor piceatannol is also an inhibitor of the rat liver cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK), rat brain Ca(2+)- and phospholipid-dependent protein kinase C (PKC), avian gizzard Ca(2+)-calmodulin-dependent myosin light chain kinae (MLCK), and of wheat embryo Ca(2+)-dependent protein ...
Gideon M. Polya +2 more
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