Results 301 to 310 of about 142,215 (332)
Some of the next articles are maybe not open access.
Molecular Pharmacology, 1999
Balanol is a potent inhibitor of cyclic AMP-dependent protein kinase and protein kinase C, acting competitively with ATP with an affinity 3000 times that of ATP. We tested the capacity of balanol to inhibit representative serine- and threonine-specific protein kinases from the protein kinase subfamily that shares a common conserved catalytic core with ...
Kazunori Koide +6 more
openaire +3 more sources
Balanol is a potent inhibitor of cyclic AMP-dependent protein kinase and protein kinase C, acting competitively with ATP with an affinity 3000 times that of ATP. We tested the capacity of balanol to inhibit representative serine- and threonine-specific protein kinases from the protein kinase subfamily that shares a common conserved catalytic core with ...
Kazunori Koide +6 more
openaire +3 more sources
Effect of Glucuronidation on the Potential of Kaempferol To Inhibit Serine/Threonine Protein Kinases
Journal of Agricultural and Food Chemistry, 2016To study the effect of metabolic conjugation of flavonoids on the potential to inhibit protein kinase activity, the inhibitory effects of the dietary flavonol kaempferol and its major plasma conjugate kaempferol-3-O-glucuronide on protein kinases were studied.
Beekmann, Karsten +4 more
openaire +4 more sources
Biochemical Pharmacology, 1988
The inhibitory potencies of bioflavonoids on various tyrosine protein kinases and serine/threonine protein kinases were investigated. The phosphotransferase activity of an oncogene product, pp130fps, and a growth factor receptor, insulin receptor, were inhibited by myricetin, a derivative of quercetin.
Ito Masaaki +5 more
openaire +2 more sources
The inhibitory potencies of bioflavonoids on various tyrosine protein kinases and serine/threonine protein kinases were investigated. The phosphotransferase activity of an oncogene product, pp130fps, and a growth factor receptor, insulin receptor, were inhibited by myricetin, a derivative of quercetin.
Ito Masaaki +5 more
openaire +2 more sources
Phosphorylation of Smad Signaling Proteins by Receptor Serine/Threonine Kinases
2003Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins, and bone morphogenetic proteins (BMPs), elicit their multifunctional effects by binding to and complex formation ...
Serhiy Souchelnytskyi +3 more
openaire +3 more sources
Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N
Science, 1996Rho, a Ras-like small guanosine triphosphatase, has been implicated in cytoskeletal responses to extracellular signals such as lysophosphatidic acid (LPA) to form stress fibers and focal contacts. The form of RhoA bound to guanosine triphosphate directly bound to and activated a serine-threonine kinase, protein kinase N (PKN).
Kazuyasu Chihara +8 more
openaire +3 more sources
Protein Kinase C and Its Interactions with Other Serine-Threonine Kinases
1997Despite the diversity of platelet agonists, ranging from soluble molecules that bind to receptors on the platelet surface to shear stress (Kroll et al. 1993) and various artificial surfaces (Ware et al. 1991), the changes in platelet function that they induce are stereotypical. These include cytoskeletal reorganization (shape change), conversion of the
J. D. Chang, J. A. Ware
openaire +2 more sources
Protein Serine/Threonine Kinases of the MAPK Cascade
Annals of the New York Academy of Sciences, 1995Jonathan D. Graves +2 more
openaire +2 more sources
Beyond PI3Ks: targeting phosphoinositide kinases in disease
Nature Reviews Drug Discovery, 2023Joanna Triscott +2 more
exaly
Regulation of glycolysis by Raf protein serine/threonine kinases
Advances in Enzyme Regulation, 2002Sybille Mazurek +10 more
openaire +3 more sources
Serine-Threonine Kinase Receptor-Associated Protein
2008Nilesh D. Kashikar, Pran K. Datta
openaire +1 more source