Results 71 to 80 of about 142,215 (332)

Subcellular partitioning of protein kinase activity revealed by functional kinome profiling

Scientific Reports, 2022
Protein kinases and their substrates form signaling networks partitioned across subcellular compartments to facilitate critical biological processes. While the subcellular roles of many individual kinases have been elucidated, a comprehensive assessment ...
Lauren Wegman-Points, Khaled Alganem, Ali Sajid Imami, Victoria Mathis, Justin Fortune Creeden, Robert McCullumsmith, Li-Lian Yuan   +6 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Biology and pharmacological inhibition of homeodomain-interacting protein kinases

Frontiers in Chemical Biology
Homeodomain-interacting protein kinases (HIPKs) represent a relatively underexplored sub-family of serine/threonine protein kinases. However, the recently published studies point to the role of HIPKs in the developmental biology and etiology of ...
Adam Štefek, Adam Štefek, Kamil Paruch, Kamil Paruch   +3 more
doaj   +1 more source

A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma

BMC Cancer, 2020
Background Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CCA recurrence is not well ...
Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun, Watcharin Loilome   +7 more
doaj   +1 more source

Diversity in Serine/Threonine Protein Kinase-4 Deficiency and Review of the Literature

The Journal of Allergy and Clinical Immunology: In Practice, 2021
Serine/threonine kinase-4 (STK4) deficiency is an autosomal recessive combined immunodeficiency.We aimed to define characteristic clinical and laboratory features to aid the differential diagnosis and determine the most suitable therapy.In addition to nine STK4 deficiency patients, we reviewed 15 patients from the medical literature.
Deniz Cagdas, Sevil Oskay Halacli, Cagman Tan, Saliha Esenboga, Betül Karaatmaca, Pınar Gur Cetinkaya, Burcu Balcı-Hayta, Arzu Ayhan, Aysegul Uner, Diclehan Orhan, Kaan Boztug, Seza Ozen, Rezan Topaloglu, Ozden Sanal, Ilhan Tezcan   +14 more
openaire   +5 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Exosomes and their roles in the chemoresistance of pancreatic cancer

Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022
Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan, Honglin Tang, Qijun Li, Guangpeng Chen, Da Li   +4 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation [PDF]

, 2006
The induction of late long-term potentiation (L-LTP) involves complex interactions among second messenger cascades. To gain insights into these interactions, a mathematical model was developed for L-LTP induction in the CA1 region of the hippocampus. The differential equation-based model represents actions of protein kinase A (PKA), MAP kinase (MAPK ...
arxiv   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source