Results 101 to 110 of about 180,875 (351)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Making the Bend: DNA Tertiary Structure and Protein-DNA Interactions
International Journal of Molecular Sciences, 2014 DNA structure functions as an overlapping code to the DNA sequence. Rapid progress in understanding the role of DNA structure in gene regulation, DNA damage recognition and genome stability has been made.
S. Harteis, S. Schneider
semanticscholar +1 more source
Prediction of Protein Function Using Statistically Significant Sub-Structure Discovery [PDF]
, 2007 Proteins perform a vast number of functional roles. The number of protein structures available for analysis continues to grow and, with the development of methods to predict protein structure directly from genetic sequence without imaging technology, the
Lucas, Craig
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
The Phyre2 web portal for protein modelling, prediction and analysis
Nature Protocols, 2015 Phyre2 is a suite of tools available on the web to predict and analyze protein structure, function and mutations. The focus of Phyre2 is to provide biologists with a simple and intuitive interface to state-of-the-art protein bioinformatics tools.
L. Kelley +4 more
semanticscholar +1 more source
Utilizing protein structure to identify non-random somatic mutations [PDF]
BMC Bioinformatics, 2013 Human cancer is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes within the genome. In the case of oncogenes, recent theory suggests that there are only a few key “driver” mutations responsible for tumorigenesis.
Gregory A. Ryslik +4 more
semanticscholar +1 more source
, 2007 We present CATHEDRAL, an iterative protocol for determining the location of previously observed protein folds in novel multidomain protein structures. CATHEDRAL builds on the features of a fast secondary-structure-based method ( using graph theory) to ...
Oliver C Redfern +22 more
core +1 more source
Analysis of ORF5 protein signifies its importance in Norway rat Hepatitis E virus [PDF]
Network Biology, 2022 Hepatitis E virus (HEV) is the chief cause of hepatitis E (inflammation of liver) across the globe. The Norway rat HEV genome consists of six open reading frames (ORFs), i.e., ORF1, ORF2, ORF3, ORF4, ORF5 and ORF5.
Zoya Shafat +2 more
doaj
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
The Mrs1 splicing factor binds the bI3 group I intron at each of two tetraloop-receptor motifs. [PDF]
PLoS ONE, 2010 Most large ribozymes require protein cofactors in order to function efficiently. The yeast mitochondrial bI3 group I intron requires two proteins for efficient splicing, Mrs1 and the bI3 maturase. Mrs1 has evolved from DNA junction resolvases to function
Caia D S Duncan, Kevin M Weeks
doaj +1 more source