Results 91 to 100 of about 3,699,805 (346)

Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins

eLife, 2017
Recent functional, proteomic and ribosome profiling studies in eukaryotes have concurrently demonstrated the translation of alternative open-reading frames (altORFs) in addition to annotated protein coding sequences (CDSs). We show that a large number of
Sondos Samandi, Annie V Roy, Vivian Delcourt, Jean-François Lucier, Jules Gagnon, Maxime C Beaudoin, Benoît Vanderperre, Marc-André Breton, Julie Motard, Jean-François Jacques, Mylène Brunelle, Isabelle Gagnon-Arsenault, Isabelle Fournier, Aida Ouangraoua, Darel J Hunting, Alan A Cohen, Christian R Landry, Michelle S Scott, Xavier Roucou   +18 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution

Nature Communications, 2020
Several coronaviruses infecting humans and animals have emerged in recent years. Here, the authors provide structures of the spike proteins of the porcine coronavirus SADS-CoV and closely related bat coronavirus HKU2, providing insights into evolution of
Jinfang Yu, Shuyuan Qiao, Runyu Guo, Xinquan Wang   +3 more
doaj   +1 more source

Does a Simple Lattice Protein Exhibit Self-Organized Criticality? [PDF]

, 2015
There are many unanswered questions when it comes to protein folding. These questions are interesting because the tertiary structure of proteins determines its functionality in living organisms.
Bajracharya, Arun, Gibbon, Dana M., Runyon, Alissa A.   +2 more
core   +1 more source

Empirical Potential Function for Simplified Protein Models: Combining Contact and Local Sequence-Structure Descriptors

, 2006
An effective potential function is critical for protein structure prediction and folding simulation. Simplified protein models such as those requiring only $C_\alpha$ or backbone atoms are attractive because they enable efficient search of the ...
Adamian, Anfinsen, Avbelj, Bahar, Bastolla, Betancourt, Brooks, Buchete, Cannata, Chiu, Cline, Crasto, Dill, Dill, Dima, Dobson, Fain, Fitzkee, Fletcher, Friedrichs, Gan, Goldstein, Guntert, Hao, Head-Gordon, Hou, Hu, Hunter, Joachims, Kolinski, Kolodny, Kuang, Lazaridis, Levinthal, Levitt, Lezon, Li, Li, Liang, Loose, Lu, Maiorov, McConkey, McGuffin, Mirny, Miyazawa, Murphy, Park, Park, Pearlman, Pei, Przytycka, Riddle, Sagot, Samudrala, Samudrala, Schölkopf, Shortle, Shortle, Simons, Simons, Simons, Thomas, Tobi, Tobi, Tsai, Vendruscolo, Vendruscolo, Vriend, Wang, Wang, Xia, Xia, Zhang, Zhang, Zhang, Zhou   +76 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Crosstalk between lncRNAs and Wnt/β-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response

Non-coding RNA Research
Lung cancer (LC) is considered to have the highest mortality rate around the world. Because there are no early diagnostic signs or efficient clinical alternatives, distal metastasis and increasing numbers of recurrences are a challenge in the clinical ...
Ting Wu, YiRan Dong, XinZhi Yang, Liang Mo, Yong You   +4 more
doaj   +1 more source

Research on the Structure of Peanut Allergen Protein Ara h1 Based on Aquaphotomics [PDF]

, 2021
Mengqi Zhang, Liang Liu, Cui Yang, Zhongyu Sun, Xiuhua Xu, Lian Li, Hengchang Zang   +6 more
openalex   +1 more source

Baculovirus structural proteins

Journal of General Virology, 1992
Introduction. Baculovirus biology. The Baculoviridae are a diverse family of virus pathogens which are infectious for arthropods, particularly insects of the order Lepidoptera. They have also been isolated from the insect orders Hymenoptera, Diptera and Trichoptera, as well as from the crustacean order Decapoda (shrimp) (Couch, 1974).
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source