Results 91 to 100 of about 19,302,461 (314)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Crystal enigma: Understanding diverse protein conformational dynamics, ligand selectivity and interaction in multi-space group crystals using computational modelling

Results in Chemistry
Empirical structural methods have been instrumental in drug design, but they often fall short of capturing protein dynamics. To address this limitation, computer-aided drug design (CADD) is essential.
Mbalenhle Mfeka, Olalekan Onisuru, Ramesh Pandian, Yasien Sayed, Thandeka Khoza, Ikechukwu Achilonu   +5 more
doaj   +1 more source

VarSite: Disease variants and protein structure

Protein Science, 2019
VarSite is a web server mapping known disease‐associated variants from UniProt and ClinVar, together with natural variants from gnomAD, onto protein 3D structures in the Protein Data Bank.
R. Laskowski, J. Stephenson, I. Sillitoe, C. Orengo, J. Thornton   +4 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli

Nature Communications, 2016
Nucleotide excision repair is able to identify and remove a wide range of DNA helix distorting lesions from the genome. Here the authors use single molecule imaging of UvrA and UvrB molecules and suggest a two-step ‘scan and recruit’ model for UvrA ...
Mathew Stracy, Marcin Jaciuk, Stephan Uphoff, Achillefs N. Kapanidis, Marcin Nowotny, David J. Sherratt, Pawel Zawadzki   +6 more
doaj   +1 more source

Tissue-specific changes in apoplastic proteins and cell wall structure during cold acclimation of winter wheat crowns [PDF]

, 2017
Ian R. Willick, Daisuke Takahashi, Brian Fowler, Matsuo Uemura, Karen Tanino   +4 more
openalex   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Dynamic New World: Refining Our View of Protein Structure, Function and Evolution [PDF]

, 2014
Ranjan V. Mannige
openalex   +1 more source

Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Learning biological properties from sequence data is a logical step toward generative and predictive artificial intelligence for biology.
Alexander Rives, Siddharth Goyal, Joshua Meier, Demi Guo, Myle Ott, C. L. Zitnick, Jerry Ma, R. Fergus   +7 more
semanticscholar   +1 more source