Results 111 to 120 of about 2,069,772 (318)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Protein–fragment complex structures derived by NMR molecular replacement

, 2020
Felix Torres, Dhiman Ghosh, Dean Strotz, N. Celestine, Ben Davis, Julien Orts   +5 more
openalex   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach [PDF]

, 2017
Tonghui Huang, Jie Sun, Shanshan Zhou, Jian Gao, Yi Liu   +4 more
openalex   +1 more source

ON THE COLINEARITY OF GENE STRUCTURE AND PROTEIN STRUCTURE [PDF]

Proceedings of the National Academy of Sciences, 1964
C, YANOFSKY, B C, CARLTON, J R, GUEST, D R, HELINSKI, U, HENNING   +4 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis

Nature Communications
Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis.
Shintaro Aibara, Astrid Kassner, Edmond Wong, Karin Klingel, Monika Papworth, Magnus Althage, Qing-Dong Wang, Claudia Correia, Hendrik Milting, Taiana Maia de Oliveira   +9 more
doaj   +1 more source

Characterization of sensory and motor dysfunction and morphological alterations in late stages of type 2 diabetic mice

Frontiers in Endocrinology
Diabetic neuropathy is the most common complication of diabetes and lacks effective treatments. Although sensory dysfunction during the early stages of diabetes has been extensively studied in various animal models, the functional and morphological ...
Ting Tian, Ting Tian, Haofeng Li, Sensen Zhang, Maojun Yang, Maojun Yang   +5 more
doaj   +1 more source

Structure and function of proteins

Bioscience Reports, 1988
It is now many years since Linderstr6m-Lang suggested that the threedimensional conformation of a protein is the end result of its primary, secondary and tertiary structures. The protein's primary structure is represented by its amino acid sequence and the secondary structure by its tr-helices and E-sheets; its final three-dimensional conformation is ...
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source