Results 121 to 130 of about 19,302,461 (314)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Membrane protein isolation and structure determination in cell-derived membrane vesicles
, 2023 Xiao Tao, Chen Zhao, Roderick MacKinnon
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Insights into the structure and aggregation of lens crystallins and other aggregation-prone proteins
, 2020 Aidan B. Grosas
openalex +2 more sources
Chiral Sum Frequency Generation Spectroscopy for Characterizing Protein Secondary Structures at Interfaces [PDF]
, 2011 Li Fu, Jian Liu, Elsa C. Y. Yan
openalex +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors [PDF]
, 2009 Mohamed Aittaleb +2 more
openalex +1 more source
Phylogenetic analysis of plant multi-domain SEC14-like phosphatidylinositol transfer proteins and structure–function properties of PATELLIN2 [PDF]
, 2020 Karolin Montag +3 more
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
An optimal distance cutoff for contact-based Protein Structure Networks using side-chain centers of mass [PDF]
, 2017 Juan Salamanca Viloria +3 more
openalex +1 more source