Results 131 to 140 of about 2,069,772 (318)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Viro3D: a comprehensive database of virus protein structure predictions. [PDF]

Mol Syst Biol
Litvin U, Lytras S, Jack A, Robertson DL, Hughes J, Grove J.   +5 more
europepmc   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Aggrescan4D: structure-informed analysis of pH-dependent protein aggregation [PDF]

Oriol Bárcenas, Aleksander Kuriata, Mateusz Zalewski, Valentín Iglesias, Carlos Pintado‐Grima, Grzegorz Firlik, Michał Burdukiewicz, Sebastian Kmiecik, Salvador Ventura   +8 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

From sequence to structure and back again: approaches for predicting protein-DNA binding. [PDF]

, 2004
Annette Höglund, Oliver Kohlbacher
openalex   +1 more source

Simplified heavy-atom derivatization of protein structures via co-crystallization with the MAD tetragon tetrabromoterephthalic acid

, 2021
Jia Q. Truong, Stephanie Nguyen, John B. Bruning, Keith E. Shearwin   +3 more
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Structure and mechanism of Zorya anti-phage defense system [PDF]

BIO Web of Conferences
Hu Haidai, Hughes Thomas C.D., Popp Philipp F., Roa-Eguiara Aritz, Martin Freddie J.O., Rutbeek Nicole R., Hendriks Ivo Alexander, Payne Leighton J., Yan Yumeng, de Sousa Victor Klein, Wang Yong, Nielsen Michael Lund, Berry Richard M., Erhardt Marc, Jackson Simon A., Taylor Nicholas M.I.   +15 more
doaj   +1 more source

Structure and Dynamics of Intrinsically Disordered and Unfolded Proteins: Investigations using Small-Angle Scattering and Neutron Spin-Echo Spectroscopy [PDF]

, 2019
Felix Ameseder, Laura Stingaciu, Aurel Rădulescu, Olaf Holderer, Péter Falus, M. Monkenbusch, Ralf Biehl, Dieter Richter, Andreas Stadler   +8 more
openalex   +1 more source