Results 171 to 180 of about 3,699,805 (346)

Structure and mechanism of Zorya anti-phage defense system [PDF]

BIO Web of Conferences
Hu Haidai, Hughes Thomas C.D., Popp Philipp F., Roa-Eguiara Aritz, Martin Freddie J.O., Rutbeek Nicole R., Hendriks Ivo Alexander, Payne Leighton J., Yan Yumeng, de Sousa Victor Klein, Wang Yong, Nielsen Michael Lund, Berry Richard M., Erhardt Marc, Jackson Simon A., Taylor Nicholas M.I.   +15 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

AlphaFold in protein structure and function prediction. [PDF]

Comput Struct Biotechnol J
Kurgan L, Yang J.
europepmc   +1 more source

Binding affinity of pAPN with the S proteins of PEDV, TGEV, and SADS-CoV revealed by docking structure and SPR.

Da An (21627567), Yan Li (23143), Yi Pei (54574), Yong-Hao Ma (2869658), Fei Yao (43685), Yongzhi Feng (11861457), Yanke Shan (5978276), Fei Liu (21082)   +7 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Protein structure-informed bacteriophage genome annotation with Phold. [PDF]

Nucleic Acids Res
Bouras G, Grigson SR, Mirdita M, Heinzinger M, Papudeshi B, Mallawaarachchi V, Green R, Kim RS, Mihalia V, Psaltis AJ, Wormald PJ, Vreugde S, Steinegger M, Edwards RA.   +13 more
europepmc   +1 more source

Nanoscale chemical characterization of secondary protein structure of F-Actin using mid-infrared photoinduced force microscopy (PiF-IR)

, 2023
Jesvin Joseph, Lukas Spantzel, Maryam Ali, Dijo Moonnukandathil Joseph, Sebastian Unger, Katharina Reglinski, Christoph Krafft, Anne-Dorothea Müller, Christian Eggeling, Rainer Heintzmann, Michael Börsch, Adrian T. Press, Daniela Täuber   +12 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Insulin as a model to teach three-dimensional structure of proteins

, 2018
João Batista Teixeira da Rocha, Cláudia Sirlene Oliveira, Pablo A. Nogara, Gabriela Luisa Schmitz   +3 more
openalex   +1 more source