Results 91 to 100 of about 410,461 (311)

Prediction of zinc-binding sites in proteins from sequence

, 2008
MOTIVATION: Motivated by the abundance, importance and unique functionality of zinc, both biologically and physiologically, we have developed an improved method for the prediction of zinc-binding sites in proteins from their amino acid sequences. RESULTS:
Hovmöller, Sven,, Shu, Nanjiang,, Zhou, Tuping,   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Structure and function prediction of human homologue hABH5 of _E. coli_ ALKB5 using in silico approach

, 2011
Newly discovered human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Little is known about the structure and function of hABH5, one of the members of this superfamily.
shankaracharya shankaracharya, Mr. Shankaracharya, Ambarish Sharan Vidyarthi, null Shankaracharya, Saibal Das   +4 more
core   +1 more source

Constraint Guided Neighbor Generation for Protein Structure Prediction

, 2022
Protein structure prediction (PSP) is essential for drug discovery. PSP involves minimising an unknown scoring function over an astronomical search space.
Newton, MA Hakim, Sattar, Abdul, Zaman, Rianon, Mataeimoghadam, Fereshteh   +3 more
core   +1 more source

Integration of Multi-Feature Fusion and PLS-DA in Protein Secondary Structure Prediction

MATEC Web of Conferences, 2016
Protein structure prediction has become one of the central problems in the field of modern computational biology. Protein secondary structure prediction is the basis of the spatial structure prediction of proteins.
Huang Guangzao, Tang Meishuang, Guan Jinting, Zhou Sun, Zhu Wenbing, Ji Guoli   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Why similar protein sequences encode similar three-dimensional structures? [PDF]

, 2010
Evolutionarily related proteins have similar sequences. Such similarity is called homology and can be described using substitution matrices such as Blosum 60.
Zielenkiewicz, Piotr, Kaczanowski, Szymon   +1 more
core  

Artificial intelligence for template-free protein structure prediction: a comprehensive review

, 2022
Protein structure prediction (PSP) is a grand challenge in bioinformatics, drug discovery, and related fields. PSP is computationally challenging because of an astronomically large conformational space to be searched and an unknown very complex energy ...
Mufassirin, MMM, Newton, MAH, Sattar, A
core   +1 more source

Hohai Graphic Protein Data Bank and Prediction Model [PDF]

Jisuanji kexue
Protein is a kind of substance with spatial structure.The main goal of protein structure prediction is to extract effective information from existing large-scale protein datasets,so as to predict the structure of proteins in nature.At present,one of the ...
WEI Xiangxiang, MENG Zhaohui
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source