Results 111 to 120 of about 410,461 (311)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

WeFold: A coopetition for protein structure prediction

, 2014
The protein structure prediction problem continues to elude scientists. Despite the introduction of many methods, only modest gains were made over the last decade for certain classes of prediction targets.
Levitt, Michael, He, Yi, Flatten, Jeff, Xu, Kefan, Khoury, George A, Wirecki, Tomasz, Smadbeck, James, Liwo, Adam, Keasar, Chen, Skolnick, Jeffrey, Bortot, Leandro O, Delbem, Alexandre CB, Deng, Xin, Krupa, Pawel, Baker, David, Cheng, Jianlin, Mozolewska, Magdalena A, Floudas, Christodoulos A, Scheraga, Harold A, Faccioli, Rodrigo A, Bacardit, Jaume, Crivelli, Silvia N, Li, Jilong, Popović, Zoran, Cooper, Seth, Players, Foldit, Zhou, Hongyi, Chopra, Gaurav, Sieradzan, Adam K, Khatib, Firas   +29 more
core   +1 more source

RaptorX-Angle: real-value prediction of protein backbone dihedral angles through a hybrid method of clustering and deep learning

BMC Bioinformatics, 2018
Background Protein dihedral angles provide a detailed description of protein local conformation. Predicted dihedral angles can be used to narrow down the conformational space of the whole polypeptide chain significantly, thus aiding protein tertiary ...
Yujuan Gao, Sheng Wang, Minghua Deng, Jinbo Xu   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

DeepCDpred: Inter-residue distance and contact prediction for improved prediction of protein structure.

PLoS ONE, 2019
Rapid, accurate prediction of protein structure from amino acid sequence would accelerate fields as diverse as drug discovery, synthetic biology and disease diagnosis.
Shuangxi Ji, Tuğçe Oruç, Liam Mead, Muhammad Fayyaz Rehman, Christopher Morton Thomas, Sam Butterworth, Peter James Winn   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Describing and Comparing Protein Structures Using Shape Strings

, 2008
Different methods for describing and comparing the structures of the tens of thousands of proteins that have been determined by X-ray crystallography are reviewed.
Hovmöller, Sven,, Shu, Nanjiang,, Zhou, Tuping,   +2 more
core  

NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]

, 2011
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
Alaol Kabir, Kabir, Alaol, Sakib, Kazi, Kazi Sakib, Hossain, Alamgir, Islam, Md Saiful, Islam, Md. Saiful, Hossain, Md Alamgir, Md. Alamgir Hossain, Md. Saiful Islam   +9 more
core   +1 more source

Limitations of Protein Structure Prediction Algorithms in Therapeutic Protein Development

BioMedInformatics
The three-dimensional protein structure is pivotal in comprehending biological phenomena. It directly governs protein function and hence aids in drug discovery. The development of protein prediction algorithms, such as AlphaFold2, ESMFold, and trRosetta,
Sarfaraz K. Niazi, Zamara Mariam, Rehan Z. Paracha   +2 more
doaj   +1 more source

Hill-Climbing search and diversification within an evolutionary approach to protein structure prediction

BioData Mining, 2011
Proteins are complex structures made of amino acids having a fundamental role in the correct functioning of living cells. The structure of a protein is the result of the protein folding process.
Chira Camelia, Horvath Dragos, Dumitrescu D   +2 more
doaj   +1 more source