Results 291 to 300 of about 1,386,749 (339)
Some of the next articles are maybe not open access.
Predicting Protein Structures Accurately
Science, 2004In their Research Article “Design of a novel globular protein fold with atomic-level accuracy,” B. Kuhlman et al. describe an extremely successful attempt to design a new protein (Top7) that folds to a predefined structure (21 Nov, p. [1364][1]).
Marcin, von Grotthuss +3 more
openaire +2 more sources
Protein Structure Prediction and Structural Genomics
Science, 2001Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset of the proteins, computational structure ...
D, Baker, A, Sali
openaire +2 more sources
Prediction of Protein Structure
2004Publisher Summary This chapter describes the extraction of structural information from protein sequence. The deduced sequences of proteins provide invaluable insights into the functions of those proteins and the evolution of the organisms producing those proteins.
Robert H, Kretsinger +2 more
openaire +2 more sources
Protein Secondary Structure Prediction
2009While the prediction of a native protein structure from sequence continues to remain a challenging problem, over the past decades computational methods have become quite successful in exploiting the mechanisms behind secondary structure formation. The great effort expended in this area has resulted in the development of a vast number of secondary ...
Pirovano, W.A., Heringa, J.
openaire +3 more sources
State-specific protein–ligand complex structure prediction with a multiscale deep generative model
Nature Machine Intelligence, 2022The binding complexes formed by proteins and small molecule ligands are ubiquitous and critical to life. Despite recent advancements in protein structure prediction, existing algorithms are so far unable to systematically predict the binding ligand ...
Zhuoran Qiao +4 more
semanticscholar +1 more source
MO4: A Many-Objective Evolutionary Algorithm for Protein Structure Prediction
IEEE Transactions on Evolutionary Computation, 2021Protein structure prediction (PSP) problems are a major biocomputing challenge, owing to its scientific intrinsic that assists researchers to understand the relationship between amino acid sequences and protein structures, and to study the function of ...
Zhenyu Lei +4 more
semanticscholar +1 more source
2006
Abstract Over the past decade, the success of genome sequence efforts has brought about a paradigm shift in biology [1]. There is increasing emphasis on the large-scale, high-throughput examination of all genes and gene products of an organism, with the aim of assigning their functions [2]. Of course, biological function is multifaceted,
Jeffrey Skolnick, Yang Zhang
openaire +3 more sources
Abstract Over the past decade, the success of genome sequence efforts has brought about a paradigm shift in biology [1]. There is increasing emphasis on the large-scale, high-throughput examination of all genes and gene products of an organism, with the aim of assigning their functions [2]. Of course, biological function is multifaceted,
Jeffrey Skolnick, Yang Zhang
openaire +3 more sources
2014
1. Protein Structure Modeling with MODELLER Benjamin Webb, Andrej Sali 2. RaptorX Server: A Resource for Template-based Protein Structure Modeling Morten Kallberg, Gohar Margaryan, Sheng Wang, Jianzhu Ma and Jinbo Xu 3. The MULTICOM Protein Tertiary Structure Prediction System Jilong Li, Debswapna Bhattacharya, Renzhi Cao, Badri Adhikari, Xin Deng ...
openaire +2 more sources
1. Protein Structure Modeling with MODELLER Benjamin Webb, Andrej Sali 2. RaptorX Server: A Resource for Template-based Protein Structure Modeling Morten Kallberg, Gohar Margaryan, Sheng Wang, Jianzhu Ma and Jinbo Xu 3. The MULTICOM Protein Tertiary Structure Prediction System Jilong Li, Debswapna Bhattacharya, Renzhi Cao, Badri Adhikari, Xin Deng ...
openaire +2 more sources
2010
The molecular basis of life rests on the activity of large biomolecules, mostly nucleic acids(DNA and RNA), carbohydrates, lipids, and proteins. While each of these molecules has itsrole, there is something special about proteins, as they are the lead performers of cellular functions.This was dramatized by Jacques Monod, who stated that “C’est a ce ...
openaire +2 more sources
The molecular basis of life rests on the activity of large biomolecules, mostly nucleic acids(DNA and RNA), carbohydrates, lipids, and proteins. While each of these molecules has itsrole, there is something special about proteins, as they are the lead performers of cellular functions.This was dramatized by Jacques Monod, who stated that “C’est a ce ...
openaire +2 more sources
Improved protein structure prediction using potentials from deep learning
Nature, 2020A. Senior +18 more
semanticscholar +1 more source