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Predicting structures for genome proteins
Current Opinion in Structural Biology, 1999Assigning three-dimensional protein folds to genome sequences is essential to understanding protein function. Although experimental three-dimensional structures are currently available for only a very small fraction of these sequences, computational fold assignment is able to assign folds to 20-30% of the sequences in various genomes.
Daniel Fischer, David Eisenberg
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Protein Tertiary Structure Prediction
Current Protocols in Protein Science, 2000AbstractThis unit addresses how to predict the tertiary structure of a protein from its amino acid sequence using computational methods. Three types of prediction methods‐‐homology modeling, fold recognition, and ab initio prediction‐‐are introduced.
Ying Xu, Dong Xu
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Prediction of Protein Structural Classes
Critical Reviews in Biochemistry and Molecular Biology, 1995A protein is usually classified into one of the following five structural classes: alpha, beta, alpha + beta, alpha/beta, and zeta (irregular). The structural class of a protein is correlated with its amino acid composition. However, given the amino acid composition of a protein, how may one predict its structural class?
Kuo-Chen Chou, Chun-Ting Zhang
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Protein structure prediction in 2002
Current Opinion in Structural Biology, 2002Central issues concerning protein structure prediction have been highlighted by the recently published summary of the fourth community-wide protein structure prediction experiment (CASP4). Although sequence/structure alignment remains the bottleneck in comparative modeling, there has been substantial progress in fully automated remote homolog detection
David Baker +2 more
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Predicting Protein Structures Accurately
Science, 2004In their Research Article “Design of a novel globular protein fold with atomic-level accuracy,” B. Kuhlman et al. describe an extremely successful attempt to design a new protein (Top7) that folds to a predefined structure (21 Nov, p. [1364][1]).
Lucjan Wyrwicz +3 more
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Protein structure prediction and design
1998Proteins have a unique native conformation, which can be proven in many instances to be determined by the amino acid sequence alone. The folding problem, that is the understanding of how the amino acid sequence directs folding, is still unsolved, despite more than 30 years of effort. However, many new methods have appeared in the past few years.
Morea V, Leplae R, Tramontano, A
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Structure prediction of the RPE65 protein
Journal of Theoretical Biology, 2006The RPE65 protein is located in the retinal pigment epithelial cells and plays an important role in the visual cycle. Although numerous experimental results demonstrate that it participates in the visual cycle, its detailed structure and function are not clear yet because of difficulties in isolation and crystallization.
Elizabeth R. Gaillard +2 more
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Structure Predictions for Membrane Proteins
1987To predict the folding of membrane proteins one usually starts by identifying stretches of ∿ 20 hydrophobic residues on the amino acid sequence. Folded in an α-helix, these residues would span the hydrocarbon core of the lipid bilayer. Following Kyte and Doolittle (1982), a hydrophobicity index h is attributed to each amino acid residue and the mean ...
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Prediction of Protein Structure Classes
2015 International Conference on Informative and Cybernetics for Computational Social Systems (ICCSS), 2015Prediction of protein special structural plays a significant role to better recognize the protein folding patterns. Multiple prediction methods may be used to predict the structures based on the information of sequences and biostatistics. The accuracy, nevertheless, is strongly affected by the efficiency of classification, the robustness of model and ...
Jin Zhou +5 more
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2010
The molecular basis of life rests on the activity of large biomolecules, mostly nucleic acids(DNA and RNA), carbohydrates, lipids, and proteins. While each of these molecules has itsrole, there is something special about proteins, as they are the lead performers of cellular functions.This was dramatized by Jacques Monod, who stated that “C’est a ce ...
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The molecular basis of life rests on the activity of large biomolecules, mostly nucleic acids(DNA and RNA), carbohydrates, lipids, and proteins. While each of these molecules has itsrole, there is something special about proteins, as they are the lead performers of cellular functions.This was dramatized by Jacques Monod, who stated that “C’est a ce ...
openaire +2 more sources